Seroatlas · Protein domains

P-loop containing nucleoside triphosphate hydrolase

IPR027417

Definition

The P-loop NTPase fold is the most prevalent domain of the several distinct nucleotide-binding protein folds. The most common reaction catalysed by enzymes of the P-loop NTPase fold is the hydrolysis of the beta-gamma phosphate bond of a bound nucleoside triphosphate (NTP). The energy from NTP hydrolysis is typically utilised to induce conformational changes in other molecules, which constitutes the basis of the biological functions of most P-loop NTPases. P-loop NTPases show substantial substrate preference for either ATP or GTP PMID:15381417.

873 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (873 proteins: gene, accession, name)

Loading the interactive Seroatlas explorer...