GAL3ST2

Protein identityUniProt · HPA

UniProt accession

Q9H3Q3

Gene

GAL3ST2

Ensembl

ENSG00000154252

Chromosome

2

Canonical length

398 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q9H3Q3|GAL3ST2
     1  MMSMLGGLQR YFRVILLLLL ALTLLLLAGF LHSDLELDTP LFGGQAEGPP VTNIMFLKTH
    61  KTASSTVLNI LYRFAETHNL SVALPAGSRV HLGYPWLFLA RYVEGVGSQQ RFNIMCNHLR
   121  FNLPQVQKVM PNDTFYFSIL RNPVFQLESS FIYYKTYAPA FRGAPSLDAF LASPRTFYND
   181  SRHLRNVYAK NNMWFDFGFD PNAQCEEGYV RARIAEVERR FRLVLIAEHL DESLVLLRRR
   241  LRWALDDVVA FRLNSRSARS VARLSPETRE RARSWCALDW RLYEHFNRTL WAQLRAELGP
   301  RRLRGEVERL RARRRELASL CLQDGGALKN HTQIRDPRLR PYQSGKADIL GYNLRPGLDN
   361  QTLGVCQRLV MPELQYMARL YALQFPEKPL KNIPFLGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAL3ST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

8.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.89

gnomAD pLI

0

gnomAD missense Z

-0.05

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycolipid biosynthetic process
• glycoprotein biosynthetic process

Molecular functions

• galactose 3-O-sulfotransferase activity
• galactosylceramide sulfotransferase activity

Cellular components

• Golgi cisterna membrane
• membrane

Protein domainsUniProt · Pfam · InterPro

• Galactose-3-O-sulfotransferase
• P-loop containing nucleoside triphosphate hydrolase
• Galactose-3-O-sulfotransferase

KeywordsUniProt

• Glycoprotein
• Golgi apparatus
• Membrane
• Signal-anchor
• Transferase
• Transmembrane
• Transmembrane helix