Seroatlas · Human Serome Atlas

GIMAP8

GTPase IMAP family member 8

Also known as: DKFZp667I133, GIMA8_HUMAN, hIAN6, IAN9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND71
Gene: GIMAP8
Ensembl: ENSG00000171115
Chromosome: 7
Canonical length: 665 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q8ND71|GIMAP8
     1  MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ RESWVLRERK
    61  VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV IAIGHFTRED EETAKGIQQV
   121  FGAEARRHII IVFTRKDDLG DDLLQDFIEK NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT
   181  QVLELLRKVE SLVNTNGGPY HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE
   241  QNPGTSELTV LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI
   301  IDAPDISSLK NIDSEVRKHI CTGPHAFLLV TPLGFYTKND EAVLSTIQNN FGEKFFEYMI
   361  ILLTRKEDLG DQDLDTFLRN SNKALYGLIQ KCKNRYSAFN YRATGEEEQR QADELLEKIE
   421  SMVHQNGNKH CVFREKETLN IVLVGRSGTG KSATGNSILG SLVFTSRLRA QPVTKTSQSG
   481  RRTWDGQEVV VVDTPSFNQM LDVEKDPSRL EEEVKRCLSC CEKGDTFFVL VFQLGRFTEE
   541  DKTAVAKLEA IFGADFTKYA IMLFTRKEDL GAGNLEDFMK NSDNKALRRI FKKCGRRVCA
   601  FNNKETGQAQ ETQVKALLTK VNDLRKESGW SGYPHTQENV SKLIKNVQEM SQAEKLLKNL
   661  IGILQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spleen: 38 nTPM
lung: 25 nTPM
lymph node: 22 nTPM
appendix: 20 nTPM
adipose tissue: 19 nTPM
heart muscle: 17 nTPM

Single-cell type

kupffer cells: 146 nCPM
lymphatic endothelial cells: 112 nCPM
vascular endothelial cells: 111 nCPM
microglia: 88 nCPM
macrophages: 50 nCPM
monocytes: 46 nCPM

Immune cell

intermediate monocyte: 59 nTPM
non-classical monocyte: 58 nTPM
classical monocyte: 45 nTPM
total PBMC: 27 nTPM
MAIT T-cell: 18 nTPM
naive CD4 T-cell: 17 nTPM

Brain region

white matter: 7.6 nTPM
choroid plexus: 7.3 nTPM
pons: 7.1 nTPM
spinal cord: 7.1 nTPM
medulla oblongata: 7 nTPM
thalamus: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of T cell apoptotic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP8 as an antibody target. Whether an autoantibody or antibody against GIMAP8 could matter depends on whether native GIMAP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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