Seroatlas · Human Serome Atlas

IFT27

Intraflagellar transport protein 27 homolog

Also known as: BBS19, FAP156, IFT27_HUMAN, RABL4, RAYL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW83
Gene
IFT27
Ensembl
ENSG00000100360
Chromosome
22
Canonical length
186 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q9BW83|IFT27
     1  MVKLAAKCIL AGDPAVGKTA LAQIFRSDGA HFQKSYTLTT GMDLVVKTVP VPDTGDSVEL
    61  FIFDSAGKEL FSEMLDKLWE SPNVLCLVYD VTNEESFNNC SKWLEKARSQ APGISLPGVL
   121  VGNKTDLAGR RAVDSAEARA WALGQGLECF ETSVKEMENF EAPFHCLAKQ FHQLYREKVE
   181  VFRALA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 41 nTPM
  • pituitary gland: 38 nTPM
  • fallopian tube: 34 nTPM
  • basal ganglia: 33 nTPM
  • amygdala: 31 nTPM
  • hypothalamus: 29 nTPM

Single-cell type

  • epididymal efferent duct ciliated cells: 317 nCPM
  • respiratory ciliated cells: 306 nCPM
  • fallopian tube ciliated cells: 278 nCPM
  • late primary spermatocytes: 138 nCPM
  • ependymal cells: 127 nCPM
  • endometrial ciliated cells: 116 nCPM

Immune cell

  • myeloid DC: 39 nTPM
  • eosinophil: 36 nTPM
  • classical monocyte: 32 nTPM
  • plasmacytoid DC: 31 nTPM
  • non-classical monocyte: 30 nTPM
  • T-reg: 30 nTPM

Brain region

  • choroid plexus: 50 nTPM
  • midbrain: 43 nTPM
  • medulla oblongata: 38 nTPM
  • spinal cord: 36 nTPM
  • thalamus: 36 nTPM
  • pons: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFT27.

Disease | AllUniProt

Conditions IFT27 is implicated in, by any mechanism.

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 202 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT27 as an antibody target. Whether an autoantibody or antibody against IFT27 could matter depends on whether native IFT27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFT27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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