Seroatlas · Human Serome Atlas

OLA1

Obg-like ATPase 1

Also known as: GTPBP9, OLA1_HUMAN, PTD004

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NTK5
Gene: OLA1
Ensembl: ENSG00000138430
Chromosome: 2
Canonical length: 396 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q9NTK5|OLA1
     1  MPPKKGGDGI KPPPIIGRFG TSLKIGIVGL PNVGKSTFFN VLTNSQASAE NFPFCTIDPN
    61  ESRVPVPDER FDFLCQYHKP ASKIPAFLNV VDIAGLVKGA HNGQGLGNAF LSHISACDGI
   121  FHLTRAFEDD DITHVEGSVD PIRDIEIIHE ELQLKDEEMI GPIIDKLEKV AVRGGDKKLK
   181  PEYDIMCKVK SWVIDQKKPV RFYHDWNDKE IEVLNKHLFL TSKPMVYLVN LSEKDYIRKK
   241  NKWLIKIKEW VDKYDPGALV IPFSGALELK LQELSAEERQ KYLEANMTQS ALPKIIKAGF
   301  AALQLEYFFT AGPDEVRAWT IRKGTKAPQA AGKIHTDFEK GFIMAEVMKY EDFKEEGSEN
   361  AVKAAGKYRQ QGRNYIVEDG DIIFFKFNTP QQPKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 99 nTPM
tongue: 87 nTPM
cerebral cortex: 66 nTPM
thyroid gland: 56 nTPM
esophagus: 55 nTPM
thymus: 54 nTPM

Single-cell type

sertoli cells: 297 nCPM
esophageal basal cells: 288 nCPM
esophageal suprabasal cells: 288 nCPM
megakaryocyte-erythroid progenitors: 270 nCPM
late primary spermatocytes: 268 nCPM
cytotrophoblasts: 268 nCPM

Immune cell

myeloid DC: 37 nTPM
NK-cell: 26 nTPM
T-reg: 25 nTPM
classical monocyte: 25 nTPM
intermediate monocyte: 24 nTPM
MAIT T-cell: 23 nTPM

Brain region

hypothalamus: 63 nTPM
cerebral cortex: 62 nTPM
cerebellum: 59 nTPM
basal ganglia: 58 nTPM
pons: 55 nTPM
hippocampal formation: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.06
gnomAD missense Z: 1.75
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ATP metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

TGS
GTP binding domain
Beta-grasp domain superfamily
TGS-like
P-loop containing nucleoside triphosphate hydrolase
OBG-type guanine nucleotide-binding (G) domain
50S ribosome-binding GTPase
Ribosome-binding ATPase YchF/Obg-like ATPase 1
YchF, C-terminal domain
TGS-like domain superfamily
YchF, N-terminal
Protein of unknown function (DUF933)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLA1 as an antibody target. Whether an autoantibody or antibody against OLA1 could matter depends on whether native OLA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OLA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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