Seroatlas · Human Serome Atlas

RAD51B

DNA repair protein RAD51 homolog 2

Also known as: hREC2, R51H2, RA51B_HUMAN, RAD51L1, REC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15315
Gene: RAD51B
Ensembl: ENSG00000182185
Chromosome: 14
Canonical length: 384 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>O15315|RAD51B
     1  MGSKKLKRVG LSQELCDRLS RHQILTCQDF LCLSPLELMK VTGLSYRGVH ELLCMVSRAC
    61  APKMQTAYGI KAQRSADFSP AFLSTTLSAL DEALHGGVAC GSLTEITGPP GCGKTQFCIM
   121  MSILATLPTN MGGLEGAVVY IDTESAFSAE RLVEIAESRF PRYFNTEEKL LLTSSKVHLY
   181  RELTCDEVLQ RIESLEEEII SKGIKLVILD SVASVVRKEF DAQLQGNLKE RNKFLAREAS
   241  SLKYLAEEFS IPVILTNQIT THLSGALASQ ADLVSPADDL SLSEGTSGSS CVIAALGNTW
   301  SHSVNTRLIL QYLDSERRQI LIAKSPLAPF TSFVYTIKEE GLVLQETTFC SVTQAELNWA
   361  PEILPPQPPE QLGLQMCHHT QLIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD51B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 12 nTPM
epididymis: 8.4 nTPM
bone marrow: 7 nTPM
thymus: 5.5 nTPM
breast: 5.2 nTPM
ovary: 5.2 nTPM

Single-cell type

pituitary stem cells: 1,280 nCPM
renal connecting tubule cells: 936 nCPM
neutrophil progenitors: 822 nCPM
renal collecting duct principal cells: 704 nCPM
ependymal cells: 678 nCPM
microglia: 611 nCPM

Immune cell

basophil: 18 nTPM
memory B-cell: 15 nTPM
naive B-cell: 13 nTPM
naive CD4 T-cell: 10 nTPM
T-reg: 9.7 nTPM
naive CD8 T-cell: 9.4 nTPM

Brain region

white matter: 18 nTPM
choroid plexus: 15 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 15 nTPM
pons: 14 nTPM
thalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD51B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 632 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

RAD51B-related cancer predisposition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD51B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD51B as an antibody target. Whether an autoantibody or antibody against RAD51B could matter depends on whether native RAD51B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD51B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD51B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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