Seroatlas · Human Serome Atlas

RAB5C

Ras-related protein Rab-5C

Also known as: RAB5C_HUMAN, RAB5CL, RABL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51148
Gene
RAB5C
Ensembl
ENSG00000108774
Chromosome
17
Canonical length
216 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Endosomes

OverviewNCBI Gene

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>P51148|RAB5C
     1  MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT
    61  QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFA RAKNWVKELQ
   121  RQASPNIVIA LAGNKADLAS KRAVEFQEAQ AYADDNSLLF METSAKTAMN VNEIFMAIAK
   181  KLPKNEPQNA TGAPGRNRGV DLQENNPASR SQCCSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
192 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 192 nTPM
  • kidney: 140 nTPM
  • adipose tissue: 128 nTPM
  • duodenum: 127 nTPM
  • basal ganglia: 122 nTPM
  • small intestine: 117 nTPM

Single-cell type

  • late spermatids: 67 nCPM
  • early spermatids: 34 nCPM
  • late primary spermatocytes: 23 nCPM
  • parietal cells: 14 nCPM
  • enterocytes: 11 nCPM
  • platelets: 9.9 nCPM

Immune cell

  • neutrophil: 196 nTPM
  • eosinophil: 130 nTPM
  • classical monocyte: 120 nTPM
  • non-classical monocyte: 110 nTPM
  • intermediate monocyte: 104 nTPM
  • total PBMC: 99 nTPM

Brain region

  • thalamus: 151 nTPM
  • hypothalamus: 142 nTPM
  • medulla oblongata: 137 nTPM
  • white matter: 136 nTPM
  • cerebral cortex: 134 nTPM
  • midbrain: 133 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB5C.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 44 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.94
gnomAD missense Z
1.42
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB5C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB5C as an antibody target. Whether an autoantibody or antibody against RAB5C could matter depends on whether native RAB5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB5C is annotated at the cell surface, where native RAB5C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB5C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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