Seroatlas · Human Serome Atlas

RAB39A

Ras-related protein Rab-39A

Also known as: RAB39, RB39A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14964
Gene: RAB39A
Ensembl: ENSG00000179331
Chromosome: 11
Canonical length: 217 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Involved in phagosome acidification and phagosome-lysosome fusion. Located in phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q14964|RAB39A
     1  METIWIYQFR LIVIGDSTVG KSCLLHRFTQ GRFPGLRSPA CDPTVGVDFF SRLLEIEPGK
    61  RIKLQLWDTA GQERFRSITR SYYRNSVGGF LVFDITNRRS FEHVKDWLEE AKMYVQPFRI
   121  VFLLVGHKCD LASQRQVTRE EAEKLSADCG MKYIETSAKD ATNVEESFTI LTRDIYELIK
   181  KGEICIQDGW EGVKSGFVPN TVHSSEEAVK PRKECFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB39A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.7 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 3.7 nTPM
appendix: 2.8 nTPM
spleen: 2.8 nTPM
thymus: 2.4 nTPM
lymph node: 1.9 nTPM
tonsil: 1.3 nTPM

Single-cell type

microglia: 82 nCPM
cone photoreceptor cells: 70 nCPM
kupffer cells: 40 nCPM
retinal ganglion cells: 39 nCPM
pancreatic islet cells: 38 nCPM
macrophages: 35 nCPM

Immune cell

intermediate monocyte: 2.2 nTPM
non-classical monocyte: 1.6 nTPM
classical monocyte: 1.4 nTPM
myeloid DC: 1.1 nTPM
memory B-cell: 0.8 nTPM
naive B-cell: 0.5 nTPM

Brain region

hypothalamus: 13 nTPM
pons: 12 nTPM
medulla oblongata: 12 nTPM
hippocampal formation: 11 nTPM
cerebral cortex: 11 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 1.14
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB39A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB39A as an antibody target. Whether an autoantibody or antibody against RAB39A could matter depends on whether native RAB39A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB39A is annotated at the cell surface, where native RAB39A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB39A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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