DDX59

Protein identityUniProt · HPA

UniProt accession

Q5T1V6

Gene

DDX59

Ensembl

ENSG00000118197

Chromosome

1

Canonical length

619 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Actin filaments,Basal body

OverviewNCBI Gene

Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in cytoplasm; membrane; and nucleus. Implicated in orofaciodigital syndrome V. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q5T1V6|DDX59
     1  MFVPRSLKIK RNANDDGKSC VAKIIKPDPE DLQLDKSRDV PVDAVATEAA TIDRHISESC
    61  PFPSPGGQLA EVHSVSPEQG AKDSHPSEEP VKSFSKTQRW AEPGEPICVV CGRYGEYICD
   121  KTDEDVCSLE CKAKHLLQVK EKEEKSKLSN PQKADSEPES PLNASYVYKE HPFILNLQED
   181  QIENLKQQLG ILVQGQEVTR PIIDFEHCSL PEVLNHNLKK SGYEVPTPIQ MQMIPVGLLG
   241  RDILASADTG SGKTAAFLLP VIMRALFESK TPSALILTPT RELAIQIERQ AKELMSGLPR
   301  MKTVLLVGGL PLPPQLYRLQ QHVKVIIATP GRLLDIIKQS SVELCGVKIV VVDEADTMLK
   361  MGFQQQVLDI LENIPNDCQT ILVSATIPTS IEQLASQLLH NPVRIITGEK NLPCANVRQI
   421  ILWVEDPAKK KKLFEILNDK KLFKPPVLVF VDCKLGADLL SEAVQKITGL KSISIHSEKS
   481  QIERKNILKG LLEGDYEVVV STGVLGRGLD LISVRLVVNF DMPSSMDEYV HQIGRVGRLG
   541  QNGTAITFIN NNSKRLFWDI AKRVKPTGSI LPPQLLNSPY LHDQKRKEQQ KDKQTQNDLV
   601  TGANLMDIIR KHDKSNSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

31 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX59.

Disease | AllUniProt

Conditions DDX59 is implicated in, by any mechanism.

• Orofaciodigital syndrome 5 (OFD5) MIM:174300

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 180 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Orofaciodigital syndrome V

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.88

gnomAD pLI

0

gnomAD missense Z

0.78

DepMap mean gene effect

-0.96

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• ATP binding
• ATP hydrolysis activity
• mRNA binding
• RNA helicase activity
• zinc ion binding

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Helicase, C-terminal domain-like
• Zinc finger, HIT-type
• DEAD/DEAH-box helicase domain
• Helicase superfamily 1/2, ATP-binding domain
• RNA helicase, DEAD-box type, Q motif
• P-loop containing nucleoside triphosphate hydrolase
• DEAD box RNA helicase
• DEAD/DEAH box helicase
• Helicase conserved C-terminal domain
• HIT zinc finger

KeywordsUniProt

• ATP-binding
• Ciliopathy
• Cytoplasm
• Helicase
• Hydrolase
• Isopeptide bond
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• RNA-binding
• Ubl conjugation
• Zinc
• Zinc-finger