Seroatlas · Human Serome Atlas

EIF2S3

Eukaryotic translation initiation factor 2 subunit 3

Also known as: EIF2, EIF2G, EIF2gamma, IF2G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41091
Gene: EIF2S3
Ensembl: ENSG00000130741
Chromosome: X
Canonical length: 472 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>P41091|EIF2S3
     1  MAGGEAGVTL GQPHLSRQDL TTLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA
    61  ISGVHTVRFK NELERNITIK LGYANAKIYK LDDPSCPRPE CYRSCGSSTP DEFPTDIPGT
   121  KGNFKLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
   181  KLKHILILQN KIDLVKESQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV
   241  KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQEIEVRPGI
   301  VSKDSEGKLM CKPIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQVLGA
   361  VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV
   421  KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2S3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

ovary: 114 nTPM
lymph node: 106 nTPM
tonsil: 104 nTPM
thymus: 91 nTPM
pancreas: 89 nTPM
endometrium: 78 nTPM

Single-cell type

parietal cells: 274 nCPM
gastric chief cells: 227 nCPM
esophageal apical cells: 223 nCPM
decidual stromal cells: 221 nCPM
monocytes: 221 nCPM
fallopian secretory cells: 219 nCPM

Immune cell

naive CD4 T-cell: 187 nTPM
naive CD8 T-cell: 156 nTPM
memory B-cell: 155 nTPM
intermediate monocyte: 151 nTPM
memory CD4 T-cell: 148 nTPM
MAIT T-cell: 147 nTPM

Brain region

choroid plexus: 70 nTPM
white matter: 66 nTPM
medulla oblongata: 57 nTPM
spinal cord: 56 nTPM
thalamus: 55 nTPM
cerebellum: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF2S3.

Disease | AllUniProt

Conditions EIF2S3 is implicated in, by any mechanism.

MEHMO syndrome (MEHMO) MIM:300148

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 169 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

MEHMO syndrome

Disease | ImmuneIEDB

Conditions an epitope on EIF2S3 was assayed in.

carbamazepine allergy T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.96
gnomAD missense Z: 3.61
DepMap mean gene effect: -1.67
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cadherin binding
GTP binding
GTPase activity
translation factor activity, RNA binding
translation initiation factor activity
methionyl-initiator methionine tRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF2S3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2S3 as an antibody target. Whether an autoantibody or antibody against EIF2S3 could matter depends on whether native EIF2S3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2S3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2S3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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