Seroatlas · Human Serome Atlas

IRGM

Immunity-related GTPase family M protein

Also known as: IFI1, IRGM_HUMAN, IRGM1, LRG-47, LRG47

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1A4Y4
Gene
IRGM
Ensembl
ENSG00000237693
Chromosome
5
Canonical length
181 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>A1A4Y4|IRGM
     1  MEAMNVEKAS ADGNLPEVIS NIKETLKIVS RTPVNITMAG DSGNGMSTFI SALRNTGHEG
    61  KASPPTELVK ATQRCASYFS SHFSNVVLWD LPGTGSATTT LENYLMEMQF NRYDFIMVAS
   121  AQFSMNHVML AKTAEDMGKK FYIVWTKLDM DLSTGALPEV QLLQIRENVL ENLQKERVCE
   181  Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRGM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.7 nTPM
  • bone marrow: 0.4 nTPM
  • appendix: 0.3 nTPM
  • retina: 0.3 nTPM
  • skin: 0.3 nTPM
  • spleen: 0.3 nTPM

Single-cell type

  • thymocytes: 44 nCPM
  • epicardial cells: 32 nCPM
  • hematopoietic stem cells: 18 nCPM
  • late primary spermatocytes: 17 nCPM
  • mast cells: 14 nCPM
  • t-cells: 14 nCPM

Immune cell

  • basophil: 2.3 nTPM
  • MAIT T-cell: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM

Brain region

  • cerebellum: 4.3 nTPM
  • pons: 2.9 nTPM
  • cerebral cortex: 2.8 nTPM
  • white matter: 2.7 nTPM
  • hypothalamus: 2.6 nTPM
  • midbrain: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRGM.

Disease | AllUniProt

Conditions IRGM is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.41
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRGM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRGM as an antibody target. Whether an autoantibody or antibody against IRGM could matter depends on whether native IRGM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRGM is annotated at the cell surface, where native IRGM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IRGM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRGM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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