Seroatlas · Human Serome Atlas

DRG1

Developmentally-regulated GTP-binding protein 1

Also known as: DRG1_HUMAN, NEDD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y295
Gene: DRG1
Ensembl: ENSG00000185721
Chromosome: 22
Canonical length: 367 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q9Y295|DRG1
     1  MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA
    61  KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG
   121  IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG
   181  FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY
   241  IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG
   301  QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED
   361  VIQIVKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

testis: 150 nTPM
skeletal muscle: 105 nTPM
tongue: 79 nTPM
heart muscle: 42 nTPM
ovary: 41 nTPM
thymus: 38 nTPM

Single-cell type

late primary spermatocytes: 1,075 nCPM
late spermatids: 871 nCPM
early spermatids: 704 nCPM
oocytes: 419 nCPM
early primary spermatocytes: 185 nCPM
cytotrophoblasts: 164 nCPM

Immune cell

memory B-cell: 54 nTPM
T-reg: 51 nTPM
intermediate monocyte: 50 nTPM
total PBMC: 47 nTPM
NK-cell: 47 nTPM
eosinophil: 46 nTPM

Brain region

cerebellum: 33 nTPM
white matter: 32 nTPM
pons: 29 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 29 nTPM
spinal cord: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DRG1.

Disease | AllUniProt

Conditions DRG1 is implicated in, by any mechanism.

Tan-Almurshedi syndrome (TANALS) MIM:620641

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 33 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Tan-Almurshedi syndrome
Flexion contracture

Disease | ImmuneIEDB

Conditions an epitope on DRG1 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.33
gnomAD missense Z: 2.21
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRG1 as an antibody target. Whether an autoantibody or antibody against DRG1 could matter depends on whether native DRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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