DTYMK

Protein identityUniProt · HPA

UniProt accession

P23919

Gene

DTYMK

Ensembl

ENSG00000168393

Chromosome

2

Canonical length

212 aa

Protein class

Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables ATP binding activity and dTMP kinase activity. Involved in dTDP biosynthetic process and thymidine biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P23919|DTYMK
     1  MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK
    61  SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP
   121  DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA
   181  SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTYMK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

35 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DTYMK.

Disease | AllUniProt

Conditions DTYMK is implicated in, by any mechanism.

• Neurodegeneration, childhood-onset, with progressive microcephaly (CONPM) MIM:619847

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodegeneration, childhood-onset, with progressive microcephaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-1.43

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to growth factor stimulus
• dTDP biosynthetic process
• dTTP biosynthetic process
• dUDP biosynthetic process
• thymidine biosynthetic process

Molecular functions

• ATP binding
• dTMP kinase activity
• nucleoside diphosphate kinase activity

Cellular components

• cytoplasm
• cytosol
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• P-loop containing nucleoside triphosphate hydrolase
• Thymidylate kinase-like domain
• Thymidylate kinase
• Thymidylate kinase
• Thymidylate kinase, conserved site

KeywordsUniProt

• Acetylation
• ATP-binding
• Intellectual disability
• Kinase
• Neurodegeneration
• Nucleotide biosynthesis
• Nucleotide-binding
• Transferase