Seroatlas · Human Serome Atlas

SEPTIN11

Septin-11

Also known as: FLJ10849, SEP11_HUMAN, SEPT11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVA2
Gene
SEPTIN11
Ensembl
ENSG00000138758
Chromosome
4
Canonical length
429 aa
Protein class
Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Primary cilium,Cytosol,Mid piece,Principal piece,Annulus
Quaternary structure
Homooligomer

OverviewNCBI Gene

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q9NVA2|SEPTIN11
     1  MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET GIGKSTLMDT
    61  LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD TVGFGDQINK DDSYKPIVEY
   121  IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP
   181  IIAKADTIAK NELHKFKSKI MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST
   241  EEVKIGNKMA KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC
   301  KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK EKEAELKEAE
   361  KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVNNFQKKKA AAQLLQSQAQ QSGAQQTKKD
   421  KDKKNASFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 79 nTPM
  • placenta: 79 nTPM
  • cerebral cortex: 62 nTPM
  • kidney: 49 nTPM
  • colon: 47 nTPM
  • basal ganglia: 45 nTPM

Single-cell type

  • platelets: 518 nCPM
  • podocytes: 464 nCPM
  • extravillous trophoblasts: 463 nCPM
  • hepatic stellate cells: 387 nCPM
  • pituicytes/fscs: 291 nCPM
  • adipocytes: 289 nCPM

Immune cell

  • NK-cell: 39 nTPM
  • eosinophil: 33 nTPM
  • plasmacytoid DC: 21 nTPM
  • basophil: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • naive CD8 T-cell: 9.4 nTPM

Brain region

  • cerebral cortex: 201 nTPM
  • white matter: 197 nTPM
  • amygdala: 167 nTPM
  • basal ganglia: 160 nTPM
  • cerebellum: 148 nTPM
  • hippocampal formation: 134 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN11 as an antibody target. Whether an autoantibody or antibody against SEPTIN11 could matter depends on whether native SEPTIN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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