Seroatlas · Human Serome Atlas

XRCC2

DNA repair protein XRCC2

Also known as: FANCU, XRCC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43543
Gene: XRCC2
Ensembl: ENSG00000196584
Chromosome: 7
Canonical length: 280 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>O43543|XRCC2
     1  MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE GTGKTEMLYH
    61  LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL SQSSEEIIKY CLGRFFLVYC
   121  SSSTHLLLTL YSLESMFCSH PSLCLLILDS LSAFYWIDRV NGGESVNLQE STLRKCSQCL
   181  EKLVNDYRLV LFATTQTIMQ KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF
   241  FSKQDDSQSS NQFSLVSRCL KSNSLKKHFF IIGESGVEFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XRCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.5 nTPM
thymus: 3.6 nTPM
testis: 3.1 nTPM
lymph node: 3 nTPM
tonsil: 2.6 nTPM
appendix: 2.3 nTPM

Single-cell type

megakaryocyte progenitors: 102 nCPM
erythrocyte progenitors: 44 nCPM
early primary spermatocytes: 42 nCPM
extravillous trophoblasts: 32 nCPM
monocyte progenitors: 24 nCPM
migrating cytotrophoblasts: 23 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

cerebellum: 23 nTPM
cerebral cortex: 22 nTPM
white matter: 20 nTPM
hypothalamus: 18 nTPM
thalamus: 18 nTPM
pons: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about XRCC2.

Disease | AllUniProt

Conditions XRCC2 is implicated in, by any mechanism.

Fanconi anemia, complementation group U (FANCU) MIM:617247
Spermatogenic failure 50 (SPGF50) MIM:619145
Premature ovarian failure 17 (POF17) MIM:619146

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 839 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hereditary cancer-predisposing syndrome
Breast carcinoma
Fanconi anemia complementation group U

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rad51-like, C-terminal
DNA recombination and repair protein RecA-like, ATP-binding domain
P-loop containing nucleoside triphosphate hydrolase
Rad51
DNA repair protein XRCC2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of XRCC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XRCC2 as an antibody target. Whether an autoantibody or antibody against XRCC2 could matter depends on whether native XRCC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XRCC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XRCC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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