Seroatlas · Human Serome Atlas

DNHD1

Dynein heavy chain domain-containing protein 1

Also known as: C11orf47, CCDC35, DHCD1, DKFZp686J0796, DNHD1_HUMAN, DNHD1L, FLJ32752, FLJ35709, FLJ46184

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M86
Gene: DNHD1
Ensembl: ENSG00000179532
Chromosome: 11
Canonical length: 4753 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Mid piece,Annulus

OverviewNCBI Gene

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Implicated in spermatogenic failure 65. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

4753 residues, UniProt reviewed canonical sequence.

>Q96M86|DNHD1
     1  MVPEERRVGL SSDETSSDSL KSWHSICVLD SKEQPLACQQ KQRQFVKPVT ESEQPTVLEL
    61  LLAELRTLFS AVLQDSSPAA WRYLHAVLGL LPPYRELLVG HLDLLPFLEQ LYCWAPWVQT
   121  HLHLDLLGAI VQAFPPDSSL LDSASHADCC PQKRRLHHRP PCPACPFVQA QWSRQQVKEE
   181  LATWLRPLTL PELQRCLGIV GAQVALEEAV WLDGLSLLPL ALAADIPVRY ESSDTDNAEV
   241  EPVGRKETRS QLDYEVPREK AFQKSSTGFS PETSFLDSQV MTALKMERYL KKIHFLYLNV
   301  APSRYFRPYS LMVVPPDKVN PEHYIFSPFG ILHVHPVEGS ETMTLGTWHH HCVLWQQLQF
   361  IPFFKYCLLR KSFTCWKKNV RLQGLHRLQK FLENHLLLAV PHFGAGLLHI SRLLQELHSV
   421  SWLPQELDRC YELLDLQTAL AEEKHKALRL LHRCLNLCTS ILRLVHEDTY HMQQCLQERV
   481  QNCDRIRTGQ GSIYLQRVQH KQLEQKLKQA EAWWLQLGKF ARLVDYMICQ SLISVLEEQI
   541  TSFVANILQA PRQKPFLSSQ LVFDDHGQLS HVPCVENMIQ TLTGGLQSVK TSALQVVQSA
   601  DLKTSSDSLY SEEEDEEEDS KDEFLMPKFQ GQPSDAVSIF CGPNVGLVWP WKSHPIAGIL
   661  EVRGCRLRGQ YFPHNYKQLE EDLDNNPKIQ QALNIQQVLL EGVLCKVQEF CREHHWITGI
   721  YEFLQSWGPQ KLEDMRGGPI KNYVTLVSRL NVWQARVSSM PIELLTKGGL LLLSCHDVQA
   781  EMESKLNSIR KDILAHVQNE CWNLSQQLMT ELTDFMHIFR TINSDIHAIA QCTQKLNEAN
   841  EQYVELEERM EYVRALHELI RNHFSLFSAE NEALDISVRR QFGESPIPPC PPPPQPHLLH
   901  CPLLAPQLLD MWEAFQFEKS QASEFLLSKR HAIMPKLQQL MAAALAELEG LLAKALSGPF
   961  MDPTQDQRST EHQLVSLERQ FQNTVSDLSE LHHAYAIFTE DETPVPLPIC GTRPIVQQQR
  1021  IWHLYRVISE NISEWKCMAF AKFSPAMAQE KTEGWLTEAA RMSTTLELHS PVLQHCMRIL
  1081  GEFRSYLPLL TKLGSLHPQS LNCQCLLRAL GLGSLQTIEL LTLGQLLTYP LLEFADRINQ
  1141  VWQNENERIH AQETIRRLQR YWEARQLRLL NFILHVPYEP PASERSKRQV LRSPQWEVVD
  1201  KDSGTFILSD YSNLQDSIQE SLQVLSKILA IEKSGDLNKI ALEWVAIMHG LGALLEVWLT
  1261  FQQKWIFLNK VLHEMKIQFP NADLNSRFKV MDDQYRTLMR ISVADPMVLS LVVPSAERSP
  1321  YFQGQQLQQL LQAGSVELEG IIMSLESVLY GVCAHFPRLF FLSDSELVAL LAARLESCEA
  1381  QLWVRRCFPH VHAVSFRSCP TGEKNTDDWE SSPNTQTQVE ALAVLGAGGE EVKLQGPLPL
  1441  HPDLPKWLAS LEKCLRLALV HMLQGCVAAR LARGPSLGEA LKQLPKQNKL YLQLYVQHWI
  1501  DLVQAFPWQC VLVAEEVVWR AEMEEALLEW GTLAMVSMHM RKLEVLVNFM RAQRASQGGQ
  1561  SLPSVRQTSL LSALLVMAVT HRDIAQLLEQ HQVSDLTDFH WVRQLKYHLG SPHIIPKSPL
  1621  QSLKTIASSE PSLSPAACWI DVLGRSFLYN YEYLGPRLGP LPSLLPERPA LVLLLALEEV
  1681  ACGTVLGPNG VGKRAIVNSL AQALGRQLVM LPCSPQIEAQ CLSNYLNGAL QGGAWLLLEK
  1741  VHQLPPGLLS ALGQRLGELH HLYAPLYQEA SRNTSTIDPT QPQLLGSSFF EKHHVSVRLG
  1801  YGCLLVLRAL SSAVPANLHL LLRPVALALP DLRQVAELTL LGAGMRDAFQ MATRLSKFFS
  1861  LERELVSGPL PCRLPLLKQI LEDTIRTLNV TKEEPKCQKP RSLAAIEEAA LLRSPLFSIL
  1921  NGLHLHNLRG LLCALFPSAS QVLAEPMTYK LMKPLVVEEL QQVGLDPSPD ILGSLEQLSQ
  1981  ALSRASGILL LGPAGSGKTT CWHSLFKIQN RLAAMEDTST QGCQPVEITH LYPSGLSPQE
  2041  FLGWLEGSCW HHGIFPKVLR AAGQCNNMGQ KRQTEESIGI QHWIICDGAS NGAWLDSITC
  2101  LLSELPQLSL PSGQQIARPP GTFLLMEVAD TTGISPTVVG CCALVWCGGE QTWQCILSAL
  2161  MASLPYEYRL QHRTVAELNH MAEVLVPATL RFLTCQGVSS LLQVHGQQAV CAGVAEVTSM
  2221  ARILHSLLDL HLRLKEEKAP GPEDLSYSDP VAQSFRSSKS SFLNRSQVDS DDVPDKCREH
  2281  LLAVSSFLFA LIWGFGAHLP SRFWPIFDTF IRDSISRLSN YPEPPPSALV FDLHVSPEDG
  2341  TLVPFTGQYL SSHIKGTLGT FHPSIQTERL LYVVDLLLSG GQPVLLAGEA ATGKSAFVEV
  2401  LVEPHHPYIY SPIHPAFSSS HLRLLLSRGI QGQTQASPQP GHHQDSKPSL LFLLEDLHLA
  2461  TSDPEKSCQP VLETLRQAMD GTVYAHSTLE LQTLQPTVNF LATVTVPGYC ERPLCPRLFR
  2521  LFTVLALESM TQATLLERHV PIIQAWLERF PSVERERALA RGLVRASVEA WEAVCNCFMP
  2581  SPLHPHYHFS LHSVSHLLSS LQLLPNRTGS RGFVDYPNHQ EHLRRVSGLR GTCLTVMMAT
  2641  RNVVRLWLHE AQRTFCDRLD SPRERSYCAK LLLVVAQSVF CCGPGPQHLG KDHQESEEEE
  2701  EEERVPEVES EGELAQWEDF SNSNSETEEE EEPYGLQVAR VSNSRDPSLT PSIGPVSRGM
  2761  KESISHKIRQ EKGTRASNYR LQVRRSFKTW WQKKPQMDLI SPLLLPVLLL HPQEKPSDLV
  2821  FSQELILGPN SETPNLYLER QWEKLEEQLA TSAAQLKLSP HLARCHSMAQ HVARLVRVLA
  2881  RPRQHGLLLS GALGTGRHTA ITLASSICQA HFFHLPSGSE EAILQCLRDA SWHAGMLSQP
  2941  VALLVPSGVD LTTLHRLLAL ATSGSFPGQY TEADLDRIGE HLPRENLGVK QNIKKEMVLQ
  3001  RFHQQVCSHL HLFFLIGDKQ AHKQLPSTLF LRLLQLATAS IDRYEPWDQA ALAKVAQHHL
  3061  EGAQSVPLDD GSWKYPDLQA SIPSVAKAMA LIHLSATHYH EHLCPALPLV TPKTFLDFLD
  3121  TFLMLQQQTI LKIKNKAQRV QNALENLRML IKEHGTHANL IFDLEQQLKD SGKSLSMFQQ
  3181  QLEQSKLLYK QQLEECRHQE NLIENLARQR DALQAQREAF LEQMSKAFLE PLSQLQVADF
  3241  EEIRSYRAPP ESVVRVTDAM CDLFHHETGW ASAKQLLCTE DFYQELVFFP KEKITDSELI
  3301  KLHLILKAPG MDDAALRAVS RPAASLAAWL WAVLHYGLAH CRGLPTDLLL QQVEATLTRE
  3361  QARLGYYQFQ AQETLEHNLA LAKMVEDAQA SHNCVAKTLS QAQCGQYHKW PMKAALLTPM
  3421  RAWTTQLQKL KGRCMTVFGD TLLCSAAIIY LGPFPPLRRQ ELLDEWLALC RGFQEALGPD
  3481  DVAQALKRKQ KSVSIPPKNP LLATHSPFSI LSLLSSESEQ YQWDGNLKPQ AKSAHLAGLL
  3541  LRSPTHYSSC RWPLLLDPSN EALIWLDPLP LEENRSFAPA LTEGRGKGLM RNQKRESKTD
  3601  MKEEDDESEE SNEAEDQTKE QKAEERKNEQ EKEQEENEEK EEEKTESQGS KPAYETQLPS
  3661  LPYLSVLSGA DPELGSQLQE AAACGLPVLL TNVELGLGCE ELQWLLQREQ LSPPQVQPGF
  3721  CLYLSTTLSL CAMEKVLGCE LLKGLNVLDL GLNMEILEEQ MLHEILCREY PELETRWQDL
  3781  KIRALDTCKA VEAAEERLLT MLLFQNPKRQ KPAKFLRNIV RAQGKLCQLR AHCEELEGQK
  3841  LQEMVLWAPY RPVVWHGMAM VKALSQLQNL LPLFCMSPEN WLAVTKQALD SMKPREINHG
  3901  EDLASHLLQL RAHLTRQLLG STVTALGLTQ VPLVGALGAL ALLQATGKAS ELERLALWPG
  3961  LAASPSTVHS KPVSDVARPA WLGPKAWHEC EMLELLPPFV GLCASLAGHS SAWQAYLSLS
  4021  STVLGPAPGP GPEPLSLLQK LILWRVLRPE CLAGALADFT TSLLGRPLDE NTYAPTMPFK
  4081  HSQATQPMLI LLPPPGHPSA TLHPLTVIQK LAAKYQQGQK QLQVIALGSE AWDPVSVVVS
  4141  TLSQAMYEGH WLVLDNCHLM PHWPKELLQL LLELLGRAKV VADLESEQLL DQPESRNVST
  4201  VHRDFRLWLI VPAESSASLP AVLTQHSMPV FWNQSLELGH VLIDSVELAQ QVLYMQPPTQ
  4261  ALPLLLLHGL LLHRQLYGTR LQAHRGRWSQ VTLTQVLQTQ DQLWASLSNP RAAMQELAAS
  4321  VFYGGPLGDT EDREALISLT QACLSPSSGS WVQPHTPQSL LATLMPLPEL RELDAMAECK
  4381  AQMHLLPSPP EPRLCGLSEG PQAWLLRRQS RALLSALQRS SPVWVPESRR GAQLAERRLR
  4441  QRLVQVNRRL ESLQDLLTHV IRQDESDAPW SVLGPNARRP LEGVLETEAL ELSQLVGTLQ
  4501  RDLDCLLQQL KGAPPCPSRR CAAVAHALWT GRLPLPWRPH APAGPQPPWH WLRQLSRRGQ
  4561  LLVRYLGVGA DASSDVPERV FHLSAFRHPR RLLLALRGEA ALDQNVPSSN FPGSRGSVSS
  4621  QLQYKRLEMN SNPLHFRVEN GPNPTVPERG LLLIGLQVLH AEWDPIAGAL QDSPSSQPSP
  4681  LPPVSISTQA PGTSDLPAPA DLTVYSCPVY MGGPLGTAKL QSRNIVMHLP LPTKLTPNTC
  4741  VQRRVHVCSP PLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

testis: 9.8 nTPM
cerebellum: 5.5 nTPM
bone marrow: 4.3 nTPM
small intestine: 3.9 nTPM
retina: 3.7 nTPM
spleen: 3.6 nTPM

Single-cell type

cardiomyocytes: 300 nCPM
epicardial cells: 227 nCPM
adipocytes: 165 nCPM
myonuclei: 150 nCPM
retinal bipolar cells: 106 nCPM
rod photoreceptor cells: 90 nCPM

Immune cell

eosinophil: 0.5 nTPM
naive CD8 T-cell: 0.4 nTPM
naive B-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

white matter: 18 nTPM
pons: 17 nTPM
medulla oblongata: 16 nTPM
cerebral cortex: 15 nTPM
thalamus: 14 nTPM
hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNHD1.

Disease | AllUniProt

Conditions DNHD1 is implicated in, by any mechanism.

Spermatogenic failure 65 (SPGF65) MIM:619712

Disease | GeneticClinVar

52 pathogenic / likely-pathogenic of 1,080 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 65

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 3.48
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNHD1 as an antibody target. Whether an autoantibody or antibody against DNHD1 could matter depends on whether native DNHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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