MYH7B

Protein identityUniProt · HPA

UniProt accession

A7E2Y1

Gene

MYH7B

Ensembl

ENSG00000078814

Chromosome

20

Canonical length

1983 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

1983 residues, UniProt reviewed canonical sequence.

>A7E2Y1|MYH7B
     1  MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG ESARYLRQGY
    61  QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV TVETKDQKVL MVREAELQPM
   121  NPPRFDLLED MAMMTHLNEA SVLHNLRQRY ARWMIYTYSG LFCVTINPYK WLPVYTASVV
   181  AAYKGKRRSD SPPHIYAVAD NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA
   241  ALGDGPGKKA QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
   301  GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM NPYDYHFCSQ
   361  GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA LLHFGNMKFK QKQREEQAEA
   421  DGTESADKAA YLMGVSSGDL LKGLLHPRVR VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL
   481  FRWLVSRINQ TLDTKLPRQF FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV
   541  LEQEEYKREG IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
   601  HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET VVPIFQKSQN
   661  RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH KENLNKLMTN LRATQPHFVR
   721  CIVPNENKTP GVMDAFLVLH QLRCNGVLEG IRICRQGFPN RLLYTDFRQR YRILNPSAIP
   781  DDTFMDSRKA TEKLLGSLDL DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR
   841  SRGRLMRLEY QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
   901  LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA EERCHLLIKS
   961  KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK KDIDDLELTL AKAEKEKQAT
  1021  ENKVKNLTEE MAALDESVAR LTKEKKALQE AHQQALGDLQ AEEDRVSALT KAKLRLEQQV
  1081  EDLECSLEQE KKLRMDTERA KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS
  1141  LRVEDEQLLG AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
  1201  EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA ELGEQVDSLQ
  1261  RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT YEDQLSEAKI KVEELQRQLA
  1321  DASTQRGRLQ TESGELSRLL EEKECLISQL SRGKALAAQS LEELRRQLEE ESKAKSALAH
  1381  AVQALRHDCD LLREQHEEEA EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK
  1441  KLALRLQEAE EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
  1501  ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE NKNLQEEISD
  1561  LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL ELEETKTLRI QLELSQVKAE
  1621  VDRKLAEKDE ECANLRRNHQ RAVESLQASL DAETRARNEA LRLKKKMEGD LNDLELQLGH
  1681  ATRQATEAQA ATRLMQAQLK EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA
  1741  LEQGERSRRL AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
  1801  EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE QAALRGGKKQ
  1861  VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA YQAEEDRKNL ARMQDLVDKL
  1921  QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH ELDDAEERAD MAETQANKLR ARTRDALGPK
  1981  HKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYH7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

339 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYH7B.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 1,156 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypertrophic cardiomyopathy 1
• MYH7B-related hypertrophic cardiomyopathy
• Short stature
• Hypertrophic cardiomyopathy
• Dilated cardiomyopathy with left ventricular noncompaction

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0

gnomAD missense Z

-0.34

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of CAMKK-AMPK signaling cascade
• regulation of cardiac muscle cell contraction
• regulation of cytosolic calcium ion concentration

Molecular functions

• actin filament binding
• ATP binding
• microfilament motor activity

Cellular components

• cardiac myofibril
• cytoplasm
• membrane
• myosin filament
• myosin II complex

Protein domainsUniProt · Pfam · InterPro

• Myosin head, motor domain-like
• Myosin tail
• Myosin, SH3 domain
• Myosin S1 fragment, N-terminal
• DNA repair protein XRCC4-like, C-terminal
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin motor domain superfamily
• Myosin head (motor domain)
• Myosin tail
• Myosin N-terminal SH3-like domain

KeywordsUniProt

• Actin-binding
• ATP-binding
• Coiled coil
• Membrane
• Motor protein
• Muscle protein
• Myosin
• Nucleotide-binding
• Thick filament

InteractionsUniProt · HPA

Protein binding partners of MYH7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMYD1