Seroatlas · Human Serome Atlas

IQCA1

Dynein regulatory complex protein 11

Also known as: DRC11, DRC11_HUMAN, FLJ22527, IQCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XH1
Gene: IQCA1
Ensembl: ENSG00000132321
Chromosome: 2
Canonical length: 822 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Flagellar centriole

OverviewNCBI Gene

The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>Q86XH1|IQCA1
     1  MSNAMYNKMW HQTQEALGAL LDKEPQKMIE PQRNQVFIFQ TLATFYVKYV QIFRNLENVY
    61  DQFVHPQKRI LIRKVLDGVM GRILELKNEM VELELTEFHY FDDILQDLKL APQQLDIPIP
   121  KYFLKEKLEV IKGREKILAQ ILADSGIDTS DMKYPVKSIP FDEAVKLIQI AERARQGRLR
   181  ALFMKQIYLQ EYRAKQSKML GKKVTDTWAA ALRIQKVWRR FHQRKETEKL REEEMIFLGM
   241  NPPPLFNEVS ATVIQAEKVD RLRNEVQIKH EEDYREALVT IKNDLKLIEG VDIKENLQDQ
   301  IRHWFIECRN LTGTFPDYPD VEEGGSAIIF SDKTIQQVIE DIIANQEEEE KNKKKKKKKE
   361  KQPKKAKKQK KGTKEKNKEE DEKWKMSPSL FLPAMKEGCN AYKEIWMKKD ESWNFSQDYD
   421  PELIKEEKRK ELQSEIRIQV DELMRQELKN LKLAVDRERE RPVKAGKKKD KKGKKGKKKE
   481  KKAKKDKDLT ADRTIESLYK ELVEEGLLIQ ALKVNLSDYI GEYSYLGTTL RQVSIEPMPS
   541  LLDVRQLITL YGIWPLGSAA VHEKAPLVKS LLLAGPSGVG KKMLVHAICT ETGANLFNLS
   601  SSNIAGKYPG KNGLQMMLHA VFKVARQLQP SVVWIEDTEK TFYKKVPNAE KMNEPKRLKK
   661  HLPQILKLLK PDDRILIVGT TRRPFDAELQ SFCKVYQKII LVPRPDYASR YVLWKQIIER
   721  NGGVLTSALN VSCLAKVTDG FTQGHIVEVV KGVLTDQRIR RQIHKPLTAV EFITAITSMN
   781  PVYKEEEESF KNWYAKTPLG KKRALAITGG STEKAKDKGK RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 47 nTPM
basal ganglia: 24 nTPM
thyroid gland: 18 nTPM
amygdala: 16 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 12 nTPM

Single-cell type

ependymal cells: 413 nCPM
astrocytes: 370 nCPM
respiratory ciliated cells: 282 nCPM
choroid plexus epithelial cells: 190 nCPM
fallopian tube ciliated cells: 159 nCPM
pituitary stem cells: 159 nCPM

Immune cell

naive CD8 T-cell: 1.4 nTPM
MAIT T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

midbrain: 38 nTPM
basal ganglia: 33 nTPM
amygdala: 29 nTPM
choroid plexus: 28 nTPM
hypothalamus: 27 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule severing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCA1 as an antibody target. Whether an autoantibody or antibody against IQCA1 could matter depends on whether native IQCA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...