Seroatlas · Human Serome Atlas

RAB43

Ras-related protein Rab-43

Also known as: ISY1, RAB11B, RAB41, RAB43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YS6
Gene: RAB43
Ensembl: ENSG00000172780
Chromosome: 3
Canonical length: 212 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables GTPase activity. Involved in Golgi organization; phagosome maturation; and retrograde transport, plasma membrane to Golgi. Located in Golgi apparatus and phagocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>Q86YS6|RAB43
     1  MAGPGPGPGD PDEQYDFLFK LVLVGDASVG KTCVVQRFKT GAFSERQGST IGVDFTMKTL
    61  EIQGKRVKLQ IWDTAGQERF RTITQSYYRS ANGAILAYDI TKRSSFLSVP HWIEDVRKYA
   121  GSNIVQLLIG NKSDLSELRE VSLAEAQSLA EHYDILCAIE TSAKDSSNVE EAFLRVATEL
   181  IMRHGGPLFS EKSPDHIQLN SKDIGEGWGC GC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
bone marrow: 22 nTPM
thyroid gland: 22 nTPM
lymph node: 16 nTPM
lung: 14 nTPM
thymus: 12 nTPM

Single-cell type

microglia: 20 nCPM
choroid plexus epithelial cells: 16 nCPM
brain excitatory neurons: 11 nCPM
brain inhibitory neurons: 10 nCPM
other brain neurons: 5.5 nCPM
ependymal cells: 4.7 nCPM

Immune cell

neutrophil: 11 nTPM
naive CD4 T-cell: 2.8 nTPM
naive CD8 T-cell: 2.4 nTPM
T-reg: 2.4 nTPM
eosinophil: 2.3 nTPM
gdT-cell: 1.5 nTPM

Brain region

cerebellum: 32 nTPM
medulla oblongata: 29 nTPM
amygdala: 28 nTPM
basal ganglia: 27 nTPM
choroid plexus: 26 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.56
gnomAD missense Z: 1.37
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB43 as an antibody target. Whether an autoantibody or antibody against RAB43 could matter depends on whether native RAB43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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