Seroatlas · Human Serome Atlas

RHEB

GTP-binding protein Rheb

Also known as: RHEB_HUMAN, RHEB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15382
Gene
RHEB
Ensembl
ENSG00000106615
Chromosome
7
Canonical length
184 aa
Protein class
Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q15382|RHEB
     1  MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD
    61  TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK
   121  KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKM DGAASQGKSS
   181  CSVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHEB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
184 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 184 nTPM
  • cerebral cortex: 167 nTPM
  • basal ganglia: 153 nTPM
  • epididymis: 151 nTPM
  • tongue: 150 nTPM
  • amygdala: 144 nTPM

Single-cell type

  • syncytiotrophoblasts: 421 nCPM
  • extravillous trophoblasts: 415 nCPM
  • epididymal basal cells: 406 nCPM
  • megakaryocytes: 402 nCPM
  • epididymal principal cells: 378 nCPM
  • epididymal efferent duct absorptive cells: 311 nCPM

Immune cell

  • eosinophil: 47 nTPM
  • plasmacytoid DC: 47 nTPM
  • MAIT T-cell: 41 nTPM
  • basophil: 40 nTPM
  • total PBMC: 40 nTPM
  • T-reg: 37 nTPM

Brain region

  • cerebral cortex: 112 nTPM
  • hippocampal formation: 104 nTPM
  • hypothalamus: 97 nTPM
  • thalamus: 92 nTPM
  • pons: 92 nTPM
  • midbrain: 90 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RHEB.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 31 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.98
gnomAD missense Z
2.3
DepMap mean gene effect
-0.75
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHEB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHEB as an antibody target. Whether an autoantibody or antibody against RHEB could matter depends on whether native RHEB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHEB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHEB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHEB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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