Seroatlas · Human Serome Atlas

RAB2B

Ras-related protein Rab-2B

Also known as: FLJ14824, RAB2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUD1
Gene: RAB2B
Ensembl: ENSG00000129472
Chromosome: 14
Canonical length: 216 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q8WUD1|RAB2B
     1  MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI DGKQIKLQIW
    61  DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW LEDARQHSSS NMVIMLIGNK
   121  SDLESRRDVK REEGEAFARE HGLIFMETSA KTACNVEEAF INTAKEIYRK IQQGLFDVHN
   181  EANGIKIGPQ QSISTSVGPS ASQRNSRDIG SNSGCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
hypothalamus: 17 nTPM
retina: 17 nTPM
spinal cord: 16 nTPM
midbrain: 14 nTPM
epididymis: 14 nTPM

Single-cell type

late spermatids: 74 nCPM
melanocytes: 57 nCPM
kupffer cells: 52 nCPM
plasma cells: 49 nCPM
thymocytes: 48 nCPM
pdcs: 44 nCPM

Immune cell

basophil: 12 nTPM
plasmacytoid DC: 11 nTPM
eosinophil: 7.8 nTPM
T-reg: 7.1 nTPM
MAIT T-cell: 6.8 nTPM
naive CD8 T-cell: 6.8 nTPM

Brain region

white matter: 27 nTPM
pons: 27 nTPM
hypothalamus: 26 nTPM
midbrain: 25 nTPM
medulla oblongata: 24 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB2B as an antibody target. Whether an autoantibody or antibody against RAB2B could matter depends on whether native RAB2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB2B is annotated at the cell surface, where native RAB2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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