Seroatlas · Human Serome Atlas

RRAGC

Ras-related GTP-binding protein C

Also known as: FLJ13311, GTR2, RRAGC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB90
Gene: RRAGC
Ensembl: ENSG00000116954
Chromosome: 1
Canonical length: 399 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q9HB90|RRAGC
     1  MSLQYGAEET PLAGSYGAAD SFPKDFGYGV EEEEEEAAAA GGGVGAGAGG GCGPGGADSS
    61  KPRILLMGLR RSGKSSIQKV VFHKMSPNET LFLESTNKIY KDDISNSSFV NFQIWDFPGQ
   121  MDFFDPTFDY EMIFRGTGAL IYVIDAQDDY MEALTRLHIT VSKAYKVNPD MNFEVFIHKV
   181  DGLSDDHKIE TQRDIHQRAN DDLADAGLEK LHLSFYLTSI YDHSIFEAFS KVVQKLIPQL
   241  PTLENLLNIF ISNSGIEKAF LFDVVSKIYI ATDSSPVDMQ SYELCCDMID VVIDVSCIYG
   301  LKEDGSGSAY DKESMAIIKL NNTTVLYLKE VTKFLALVCI LREESFERKG LIDYNFHCFR
   361  KAIHEVFEVG VTSHRSCGHQ TSASSLKALT HNGTPRNAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRAGC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 35 nTPM
skin: 29 nTPM
bone marrow: 29 nTPM
placenta: 27 nTPM
blood vessel: 27 nTPM
breast: 25 nTPM

Single-cell type

syncytiotrophoblasts: 107 nCPM
esophageal apical cells: 65 nCPM
hofbauer cells: 50 nCPM
esophageal suprabasal cells: 44 nCPM
neutrophils: 44 nCPM
epididymal clear cells: 43 nCPM

Immune cell

plasmacytoid DC: 8.5 nTPM
neutrophil: 5.9 nTPM
eosinophil: 5.5 nTPM
naive B-cell: 3.6 nTPM
memory B-cell: 3.3 nTPM
MAIT T-cell: 2.9 nTPM

Brain region

midbrain: 23 nTPM
pons: 23 nTPM
white matter: 22 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 21 nTPM
thalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRAGC.

Disease | AllUniProt

Conditions RRAGC is implicated in, by any mechanism.

Long-Olsen-Distelmaier syndrome (LNGODS) MIM:620609

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Long-Olsen-Distelmaier syndrome
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRAGC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRAGC as an antibody target. Whether an autoantibody or antibody against RRAGC could matter depends on whether native RRAGC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRAGC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRAGC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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