Seroatlas · Human Serome Atlas

ATAD1

Outer mitochondrial transmembrane helix translocase

Also known as: ATAD1_HUMAN, FLJ14600, Msp1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBU5
Gene
ATAD1
Ensembl
ENSG00000138138
Chromosome
10
Canonical length
361 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoli rim,Mitochondria

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity. Involved in extraction of mislocalized protein from mitochondrial outer membrane. Located in mitochondrial outer membrane and peroxisomal membrane. Implicated in hyperekplexia 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q8NBU5|ATAD1
     1  MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE AQKQAEKLMK
    61  QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI TDLKDTVILP IKKKHLFENS
   121  RLLQPPKGVL LYGPPGCGKT LIAKATAKEA GCRFINLQPS TLTDKWYGES QKLAAAVFSL
   181  AIKLQPSIIF IDEIDSFLRN RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP
   241  QDLDSAIMRR MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK
   301  EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA FQNVLTHVCL
   361  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 33 nTPM
  • heart muscle: 32 nTPM
  • tongue: 30 nTPM
  • parathyroid gland: 27 nTPM
  • retina: 26 nTPM
  • testis: 24 nTPM

Single-cell type

  • late spermatids: 2,786 nCPM
  • early spermatids: 1,075 nCPM
  • late primary spermatocytes: 418 nCPM
  • epicardial cells: 136 nCPM
  • cardiomyocytes: 132 nCPM
  • syncytiotrophoblasts: 127 nCPM

Immune cell

  • MAIT T-cell: 10 nTPM
  • naive CD4 T-cell: 9.1 nTPM
  • naive CD8 T-cell: 8.6 nTPM
  • NK-cell: 8.6 nTPM
  • basophil: 8.4 nTPM
  • memory CD8 T-cell: 8.3 nTPM

Brain region

  • midbrain: 15 nTPM
  • hypothalamus: 15 nTPM
  • cerebellum: 15 nTPM
  • cerebral cortex: 14 nTPM
  • pons: 14 nTPM
  • thalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATAD1.

Disease | AllUniProt

Conditions ATAD1 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 214 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hyperekplexia 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
2.1
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATAD1 as an antibody target. Whether an autoantibody or antibody against ATAD1 could matter depends on whether native ATAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATAD1 is annotated at the cell surface, where native ATAD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATAD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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