IFT22
Intraflagellar transport protein 22 homolog
Also known as: DKFZp761N0823, FAP9, FLJ13225, FLJ14117, IFT22_HUMAN, RABL5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H7X7
- Gene
- IFT22
- Ensembl
- ENSG00000128581
- Chromosome
- 7
- Canonical length
- 185 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Microtubules,Mitotic spindle,Primary cilium,Basal body,Cytosol,Flagellar centriole,Mid piece,Principal piece,End piece
OverviewNCBI Gene
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
185 residues, UniProt reviewed canonical sequence.
>Q9H7X7|IFT22
1 MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS NNKGTGCEFE
61 LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME MWYSCFVQQP SLQDTQCMLI
121 AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL EDDPEEIRME FIKYLKSIIN SMSESRDREE
181 MSIMTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IFT22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 70 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 70 nTPM
- testis: 47 nTPM
- retina: 38 nTPM
- parathyroid gland: 28 nTPM
- kidney: 27 nTPM
- cerebral cortex: 26 nTPM
Single-cell type
- late spermatids: 2,180 nCPM
- late primary spermatocytes: 777 nCPM
- early spermatids: 521 nCPM
- fallopian tube ciliated cells: 311 nCPM
- epididymal efferent duct ciliated cells: 293 nCPM
- respiratory ciliated cells: 287 nCPM
Immune cell
- memory B-cell: 7.5 nTPM
- NK-cell: 6 nTPM
- naive B-cell: 5.9 nTPM
- memory CD4 T-cell: 4.9 nTPM
- plasmacytoid DC: 4.7 nTPM
- naive CD8 T-cell: 4.5 nTPM
Brain region
- choroid plexus: 29 nTPM
- hypothalamus: 17 nTPM
- basal ganglia: 17 nTPM
- hippocampal formation: 17 nTPM
- midbrain: 17 nTPM
- cerebral cortex: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.73
- gnomAD pLI
- 0.34
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IFT22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IFT22 as an antibody target. Whether an autoantibody or antibody against IFT22 could matter depends on whether native IFT22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IFT22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IFT22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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