GBP3

Protein identityUniProt · HPA

UniProt accession

Q9H0R5

Gene

GBP3

Ensembl

ENSG00000117226

Chromosome

1

Canonical length

595 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q9H0R5|GBP3
     1  MAPEIHMTGP MCLIENTNGE LVANPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG
    61  KNKGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDVKKGDNQ NDSWIFTLAV
   121  LLSSTLVYNS MGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEDSADFV SFFPDFVWTL
   181  RDFSLDLEAD GQPLTPDEYL EYSLKLTQGT SQKDKNFNLP RLCIRKFFPK KKCFVFDLPI
   241  HRRKLAQLEK LQDEELDPEF VQQVADFCSY IFSNSKTKTL SGGIKVNGPR LESLVLTYIN
   301  AISRGDLPCM ENAVLALAQI ENSAAVQKAI AHYDQQMGQK VQLPAETLQE LLDLHRVSER
   361  EATEVYMKNS FKDVDHLFQK KLAAQLDKKR DDFCKQNQEA SSDRCSALLQ VIFSPLEEEV
   421  KAGIYSKPGG YCLFIQKLQD LEKKYYEEPR KGIQAEEILQ TYLKSKESVT DAILQTDQIL
   481  TEKEKEIEVE CVKAESAQAS AKMVEEMQIK YQQMMEEKEK SYQEHVKQLT EKMERERAQL
   541  LEEQEKTLTS KLQEQARVLK ERCQGESTQL QNEIQKLQKT LKKKTKRYMS HKLKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

74 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

-0.04

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to interleukin-1
• cellular response to lipopolysaccharide
• cellular response to tumor necrosis factor
• cellular response to type II interferon
• cytolysis in another organism
• defense response to bacterium
• defense response to virus
• positive regulation of pyroptotic inflammatory response

Molecular functions

• GTP binding
• GTPase activity
• identical protein binding
• protein homodimerization activity

Cellular components

• cytoplasm
• cytoplasmic vesicle
• cytosol
• Golgi membrane
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Guanylate-binding protein/Atlastin, C-terminal
• Guanylate-binding protein, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• GB1/RHD3-type guanine nucleotide-binding (G) domain
• Guanylate-binding protein, C-terminal domain superfamily
• Guanylate-binding protein, C-terminal
• Guanylate-binding protein, N-terminal domain
• Guanylate-binding protein, C-terminal domain

KeywordsUniProt

• Antiviral defense
• Coiled coil
• Cytoplasm
• Golgi apparatus
• GTP-binding
• Hydrolase
• Immunity
• Innate immunity
• Membrane
• Nucleotide-binding

InteractionsUniProt · HPA

Protein binding partners of GBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAP4K4