Seroatlas · Human Serome Atlas

KIF19

Kinesin-like protein KIF19

Also known as: FLJ37300, KIF19_HUMAN, KIF19A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAC6
Gene: KIF19
Ensembl: ENSG00000196169
Chromosome: 17
Canonical length: 998 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Centrosome

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in axonemal microtubule depolymerization; microtubule-based movement; and plus-end specific microtubule depolymerization. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

998 residues, UniProt reviewed canonical sequence.

>Q2TAC6|KIF19
     1  MKDSGDSKDQ QLMVALRVRP ISVAELEEGA TLIAHKVDEQ MVVLMDPMED PDDILRAHRS
    61  REKSYLFDVA FDFTATQEMV YQATTKSLIE GVISGYNATV FAYGPTGCGK TYTMLGTDQE
   121  PGIYVQTLND LFRAIEETSN DMEYEVSMSY LEIYNEMIRD LLNPSLGYLE LREDSKGVIQ
   181  VAGITEVSTI NAKEIMQLLM KGNRQRTQEP TAANQTSSRS HAVLQVTVRQ RSRVKNILQE
   241  VRQGRLFMID LAGSERASQT QNRGQRMKEG AHINRSLLAL GNCINALSDK GSNKYINYRD
   301  SKLTRLLKDS LGGNSRTVMI AHISPASSAF EESRNTLTYA GRAKNIKTRV KQNLLNVSYH
   361  IAQYTSIIAD LRGEIQRLKR KIDEQTGRGQ ARGRQDRGDI RHIQAEVQLH SGQGEKAGMG
   421  QLREQLASAF QEQMDVRRRL LELENRAMEV QIDTSRHLLT IAGWKHEKSR RALKWREEQR
   481  KECYAKDDSE KDSDTGDDQP DILEPPEVAA ARESIAALVD EQKQLRKQKL ALEQRCRELR
   541  ARGRRLEETL PRRIGSEEQR EVLSLLCRVH ELEVENTEMQ SHALLRDGAL RHRHEAVRRL
   601  EQHRSLCDEI IQGQRQIIDD YNLAVPQRLE ELYEVYLREL EEGSLEQATI MDQVASRALQ
   661  DSSLPKITPA GTSLTPDSDL ESVKTLSSDA QHLQNSALPP LSTESEGHHV FKAGTGAWQA
   721  KSSSVPTPPP IQLGSLVTQE APAQDSLGSW INSSPDSSEN LSEIPLSHKE RKEILTGTKC
   781  IWVKAARRRS RALGTEGRHL LAPATERSSL SLHSLSEGDD ARPPGPLACK RPPSPTLQHA
   841  ASEDNLSSST GEAPSRAVGH HGDGPRPWLR GQKKSLGKKR EESLEAKRRK RRSRSFEVTG
   901  QGLSHPKTHL LGPHQAERIS DHRMPVCRHP APGIRHLGKV TLPLAKVKLP PSQNTGPGDS
   961  SPLAVPPNPG GGSRRATRGP RLPHGTSTHG KDGCSRHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spleen: 13 nTPM
hippocampal formation: 12 nTPM
fallopian tube: 11 nTPM
midbrain: 9.2 nTPM
basal ganglia: 8.5 nTPM
spinal cord: 7.9 nTPM

Single-cell type

respiratory ciliated cells: 101 nCPM
fallopian tube ciliated cells: 82 nCPM
endometrial ciliated cells: 57 nCPM
ependymal cells: 46 nCPM
epididymal efferent duct ciliated cells: 46 nCPM
paneth cells: 35 nCPM

Immune cell

gdT-cell: 2.1 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.6 nTPM
total PBMC: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

white matter: 28 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 15 nTPM
midbrain: 12 nTPM
thalamus: 10 nTPM
amygdala: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF19.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 228 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Non-immune hydrops fetalis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule-based movement
axonemal microtubule depolymerization
plus-end specific microtubule depolymerization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF19 as an antibody target. Whether an autoantibody or antibody against KIF19 could matter depends on whether native KIF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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