Seroatlas · Human Serome Atlas

DYNC1LI2

Cytoplasmic dynein 1 light intermediate chain 2

Also known as: DC1L2_HUMAN, DNCLI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43237
Gene
DYNC1LI2
Ensembl
ENSG00000135720
Chromosome
16
Canonical length
492 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol,End piece
Quaternary structure
Homodimer

OverviewNCBI Gene

Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>O43237|DYNC1LI2
     1  MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF
    61  GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK
   121  FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD
   181  FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL
   241  EKEHDYRDEH LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA
   301  LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH DKELAAEDEQ
   361  VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP ASVPSSSPGT SVKKPDPNIK
   421  NNAASEGVLA SFFNSLLSKK TGSPGSPGAG GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD
   481  SMVTNSSTEN EA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNC1LI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
269 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 269 nTPM
  • midbrain: 218 nTPM
  • hippocampal formation: 177 nTPM
  • amygdala: 168 nTPM
  • basal ganglia: 149 nTPM
  • hypothalamus: 131 nTPM

Single-cell type

  • salivary duct cells: 185 nCPM
  • late primary spermatocytes: 173 nCPM
  • salivary acinar cells: 172 nCPM
  • esophageal apical cells: 159 nCPM
  • schwann cells: 153 nCPM
  • neutrophil progenitors: 145 nCPM

Immune cell

  • eosinophil: 17 nTPM
  • classical monocyte: 17 nTPM
  • neutrophil: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • basophil: 14 nTPM

Brain region

  • white matter: 327 nTPM
  • spinal cord: 297 nTPM
  • basal ganglia: 280 nTPM
  • midbrain: 255 nTPM
  • medulla oblongata: 254 nTPM
  • amygdala: 252 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
1.89
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNC1LI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNC1LI2 as an antibody target. Whether an autoantibody or antibody against DYNC1LI2 could matter depends on whether native DYNC1LI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNC1LI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNC1LI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNC1LI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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