Seroatlas · Human Serome Atlas

ARL4D

ADP-ribosylation factor-like protein 4D

Also known as: ARF4L, ARL4D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49703
Gene: ARL4D
Ensembl: ENSG00000175906
Chromosome: 17
Canonical length: 201 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P49703|ARL4D
     1  MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI
    61  RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS
   121  RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL
   181  ERLYEMILKR KKAARGGKKR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

esophagus: 81 nTPM
retina: 79 nTPM
liver: 55 nTPM
skin: 44 nTPM
vagina: 39 nTPM
thyroid gland: 36 nTPM

Single-cell type

ocular epithelial cells: 483 nCPM
esophageal suprabasal cells: 412 nCPM
rod photoreceptor cells: 326 nCPM
esophageal apical cells: 322 nCPM
early spermatids: 263 nCPM
esophageal basal cells: 198 nCPM

Immune cell

naive B-cell: 36 nTPM
memory B-cell: 32 nTPM
myeloid DC: 8.4 nTPM
naive CD8 T-cell: 5.2 nTPM
gdT-cell: 5.1 nTPM
memory CD8 T-cell: 4.7 nTPM

Brain region

choroid plexus: 19 nTPM
cerebral cortex: 16 nTPM
white matter: 12 nTPM
cerebellum: 11 nTPM
basal ganglia: 10 nTPM
hippocampal formation: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.04
gnomAD missense Z: 1.98
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL4D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYTH2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL4D as an antibody target. Whether an autoantibody or antibody against ARL4D could matter depends on whether native ARL4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL4D is annotated at the cell surface, where native ARL4D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARL4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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