Seroatlas · Human Serome Atlas

NAV1

Neuron navigator 1

Also known as: DKFZp781D0314, FLJ12560, FLJ14203, KIAA1151, MGC14961, NAV1_HUMAN, POMFIL3, steerin-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEY1
Gene: NAV1
Ensembl: ENSG00000134369
Chromosome: 1
Canonical length: 1877 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules

OverviewNCBI Gene

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

1877 residues, UniProt reviewed canonical sequence.

>Q8NEY1|NAV1
     1  MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS
    61  AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK
   121  GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA
   181  EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL
   241  GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN
   301  PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM
   361  RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL
   421  SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA
   481  PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT
   541  SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS
   601  TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL
   661  APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK
   721  VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL
   781  PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC
   841  FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS
   901  STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE
   961  RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA
  1021  AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS
  1081  EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL
  1141  DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS
  1201  KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS
  1261  TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK
  1321  LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL
  1381  SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ
  1441  EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA
  1501  EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS
  1561  GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD
  1621  VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS
  1681  NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI
  1741  GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP
  1801  WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI
  1861  ESPDRETILD PNLQATL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 34 nTPM
heart muscle: 24 nTPM
cerebral cortex: 17 nTPM
adipose tissue: 15 nTPM
hippocampal formation: 13 nTPM
amygdala: 12 nTPM

Single-cell type

oligodendrocyte progenitor cells: 892 nCPM
fibro-adipogenic progenitors: 538 nCPM
myosatellite cells: 507 nCPM
cardiomyocytes: 434 nCPM
bergmann glia: 410 nCPM
extravillous trophoblasts: 306 nCPM

Immune cell

basophil: 3.4 nTPM
myeloid DC: 2.1 nTPM
plasmacytoid DC: 0.5 nTPM
memory B-cell: 0.3 nTPM
total PBMC: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

white matter: 72 nTPM
medulla oblongata: 66 nTPM
thalamus: 64 nTPM
hippocampal formation: 61 nTPM
amygdala: 60 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 4.15
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GIGYF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAV1 as an antibody target. Whether an autoantibody or antibody against NAV1 could matter depends on whether native NAV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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