Seroatlas · Human Serome Atlas

RAB31

Ras-related protein Rab-31

Also known as: Rab22B, RAB31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13636
Gene: RAB31
Ensembl: ENSG00000168461
Chromosome: 18
Canonical length: 195 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including Golgi to plasma membrane protein transport; cellular response to insulin stimulus; and receptor internalization. Located in early endosome; phagocytic vesicle; and trans-Golgi network membrane. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q13636|RAB31
     1  MMAIRELKVC LLGDTGVGKS SIVCRFVQDH FDHNISPTIG ASFMTKTVPC GNELHKFLIW
    61  DTAGQERFHS LAPMYYRGSA AAVIVYDITK QDSFYTLKKW VKELKEHGPE NIVMAIAGNK
   121  CDLSDIREVP LKDAKEYAES IGAIVVETSA KNAINIEELF QGISRQIPPL DPHENGNNGT
   181  IKVEKPTMQA SRRCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 102 nTPM
blood vessel: 101 nTPM
cerebral cortex: 95 nTPM
amygdala: 89 nTPM
midbrain: 83 nTPM
smooth muscle: 80 nTPM

Single-cell type

neutrophils: 2,274 nCPM
neutrophil progenitors: 1,343 nCPM
monocytes: 1,015 nCPM
kupffer cells: 773 nCPM
macrophages: 758 nCPM
platelets: 594 nCPM

Immune cell

basophil: 138 nTPM
neutrophil: 75 nTPM
classical monocyte: 52 nTPM
non-classical monocyte: 50 nTPM
intermediate monocyte: 47 nTPM
myeloid DC: 45 nTPM

Brain region

thalamus: 104 nTPM
medulla oblongata: 97 nTPM
midbrain: 93 nTPM
hypothalamus: 90 nTPM
spinal cord: 87 nTPM
white matter: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 1.29
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB31 as an antibody target. Whether an autoantibody or antibody against RAB31 could matter depends on whether native RAB31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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