IRGC
Interferon-inducible GTPase 5
Also known as: CINEMA, Iigp5, IIGP5_HUMAN, IRGC1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6NXR0
- Gene
- IRGC
- Ensembl
- ENSG00000124449
- Chromosome
- 19
- Canonical length
- 463 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in positive regulation of flagellated sperm motility. Located in lipid droplet and sperm mitochondrial sheath. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
463 residues, UniProt reviewed canonical sequence.
>Q6NXR0|IRGC
1 MATSKLPVVP GEEENTILMA KERLEALRTA FESGDLPQAA SHLQELLAST ESIRLEVGVT
61 GESGAGKSSL INALRGLEAE DPGAALTGVM ETTMQPSPYP HPQFPDVTLW DLPGAGSPGC
121 PADKYLKQVD FSRYDFFLLV SPRRCGAVET RLAAEILCQG KKFYFVRTKV DEDLAATRTQ
181 RPSGFREAAV LQEIRDHCAE RLREAGVADP RIFLVSNLSP ARYDFPTLVS TWEHDLPSHR
241 RHAGLLSLPD ISLEALQKKK AMLQEQVLKT ALVLGVIQAL PVPGLAAAYD DALLIHSLRG
301 YHRSFGLDDD SLAKLAEQVG KQAGDLRSVI RSPLANEVSP ETVLRLYSQS SDGAMRVARA
361 FERGIPVFGT LVAGGISFGA VYTMLQGCLN EMAEDAQRVR IKALEDDEPQ PEVSLEVASD
421 NGVEKGGSGE GGGEEAPLST CRKLGLLLKY ILDSWKKHDS EEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IRGC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 149 nTPM
Expression across tissuesHPA
Tissue
- testis: 149 nTPM
- basal ganglia: 0.1 nTPM
- breast: 0.1 nTPM
- cerebellum: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- pituitary gland: 0.1 nTPM
Single-cell type
- late spermatids: 3,335 nCPM
- early spermatids: 1,770 nCPM
- late primary spermatocytes: 326 nCPM
- sertoli cells: 9.6 nCPM
- leydig cells: 5.1 nCPM
- peritubular myoid cells: 2.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.8 nTPM
- cerebellum: 0.6 nTPM
- basal ganglia: 0.5 nTPM
- hippocampal formation: 0.5 nTPM
- pons: 0.4 nTPM
- hypothalamus: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.82
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 1.14
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IRGC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IRGC as an antibody target. Whether an autoantibody or antibody against IRGC could matter depends on whether native IRGC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IRGC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IRGC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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