TAP1

Protein identityUniProt · HPA

UniProt accession

Q03518

Gene

TAP1

Ensembl

ENSG00000168394

Chromosome

6

Canonical length

748 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum,Centriolar satellite

OverviewNCBI Gene

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

748 residues, UniProt reviewed canonical sequence.

>Q03518|TAP1
     1  MASSRCPAPR GCRCLPGASL AWLGTVLLLL ADWVLLRTAL PRIFSLLVPT ALPLLRVWAV
    61  GLSRWAVLWL GACGVLRATV GSKSENAGAQ GWLAALKPLA AALGLALPGL ALFRELISWG
   121  APGSADSTRL LHWGSHPTAF VVSYAAALPA AALWHKLGSL WVPGGQGGSG NPVRRLLGCL
   181  GSETRRLSLF LVLVVLSSLG EMAIPFFTGR LTDWILQDGS ADTFTRNLTL MSILTIASAV
   241  LEFVGDGIYN NTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNIMSRVTE DTSTLSDSLS
   301  ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLITLPLLFL LPKKVGKWYQ LLEVQVRESL
   361  AKSSQVAIEA LSAMPTVRSF ANEEGEAQKF REKLQEIKTL NQKEAVAYAV NSWTTSISGM
   421  LLKVGILYIG GQLVTSGAVS SGNLVTFVLY QMQFTQAVEV LLSIYPRVQK AVGSSEKIFE
   481  YLDRTPRCPP SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN
   541  GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHRQ VAAVGQEPQV FGRSLQENIA
   601  YGLTQKPTME EITAAAVKSG AHSFISGLPQ GYDTEVDEAG SQLSGGQRQA VALARALIRK
   661  PCVLILDDAT SALDANSQLQ VEQLLYESPE RYSRSVLLIT QHLSLVEQAD HILFLEGGAI
   721  REGGTHQQLM EKKGCYWAMV QAPADAPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

10

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

82 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAP1.

Disease | AllUniProt

Conditions TAP1 is implicated in, by any mechanism.

• MHC class I deficiency 1 (MHC1D1) MIM:604571

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 518 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• MHC class I deficiency
• MHC class I deficiency 1
• Glioma susceptibility 1

Disease | ImmuneIEDB

Conditions an epitope on TAP1 was assayed in.

• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.66

gnomAD pLI

0

gnomAD missense Z

1.77

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• antigen processing and presentation of endogenous peptide antigen via MHC class I
• cytosol to endoplasmic reticulum transport
• defense response
• peptide transport
• protein transport
• transmembrane transport

Molecular functions

• ABC-type peptide antigen transporter activity
• ADP binding
• ATP binding
• ATP hydrolysis activity
• metal ion binding
• MHC class I protein binding
• MHC class Ib protein binding
• peptide antigen binding
• peptide transmembrane transporter activity
• protein homodimerization activity
• TAP1 binding
• TAP2 binding

Cellular components

• centriolar satellite
• endoplasmic reticulum
• endoplasmic reticulum membrane
• endoplasmic reticulum-Golgi intermediate compartment membrane
• membrane
• MHC class I peptide loading complex
• phagocytic vesicle membrane
• TAP complex

Protein domainsUniProt · Pfam · InterPro

• ABC transporter-like, ATP-binding domain
• AAA+ ATPase domain
• ABC transporter type 1, transmembrane domain
• ABC transporter Tap-like
• ABC transporter-like, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• ABC transporter type 1, transmembrane domain superfamily
• Type 1 protein exporter
• ABC transporter
• ABC transporter transmembrane region

KeywordsUniProt

• Adaptive immunity
• Alternative initiation
• ATP-binding
• Endoplasmic reticulum
• Host-virus interaction
• Immunity
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Peptide transport
• Protein transport
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of TAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PSMB5
• PSMB8
• CALR
• HMOX2
• PDIA3
• TAP2
• TAPBP