Seroatlas · Human Serome Atlas

TPST2

Protein-tyrosine sulfotransferase 2

Also known as: TANGO13B, TPST2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60704
Gene
TPST2
Ensembl
ENSG00000128294
Chromosome
22
Canonical length
377 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>O60704|TPST2
     1  MRLSVRRVLL AAGCALVLVL AVQLGQQVLE CRAVLAGLRS PRGAMRPEQE ELVMVGTNHV
    61  EYRYGKAMPL IFVGGVPRSG TTLMRAMLDA HPEVRCGEET RIIPRVLAMR QAWSKSGREK
   121  LRLDEAGVTD EVLDAAMQAF ILEVIAKHGE PARVLCNKDP FTLKSSVYLS RLFPNSKFLL
   181  MVRDGRASVH SMITRKVTIA GFDLSSYRDC LTKWNKAIEV MYAQCMEVGK EKCLPVYYEQ
   241  LVLHPRRSLK LILDFLGIAW SDAVLHHEDL IGKPGGVSLS KIERSTDQVI KPVNLEALSK
   301  WTGHIPGDVV RDMAQIAPML AQLGYDPYAN PPNYGNPDPF VINNTQRVLK GDYKTPANLK
   361  GYFQVNQNST SSHLGSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
378 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 378 nTPM
  • epididymis: 105 nTPM
  • liver: 70 nTPM
  • lung: 43 nTPM
  • placenta: 39 nTPM
  • skeletal muscle: 37 nTPM

Single-cell type

  • platelets: 1,202 nCPM
  • epididymal principal cells: 360 nCPM
  • pancreatic acinar cells: 338 nCPM
  • neutrophils: 281 nCPM
  • cytotrophoblasts: 245 nCPM
  • hofbauer cells: 202 nCPM

Immune cell

  • basophil: 491 nTPM
  • NK-cell: 357 nTPM
  • gdT-cell: 251 nTPM
  • total PBMC: 240 nTPM
  • memory CD8 T-cell: 188 nTPM
  • naive CD8 T-cell: 165 nTPM

Brain region

  • thalamus: 51 nTPM
  • choroid plexus: 36 nTPM
  • cerebral cortex: 35 nTPM
  • midbrain: 31 nTPM
  • amygdala: 30 nTPM
  • spinal cord: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.27
gnomAD missense Z
1.21
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPST2 as an antibody target. Whether an autoantibody or antibody against TPST2 could matter depends on whether native TPST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPST2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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