Seroatlas · Human Serome Atlas

GNL3

Guanine nucleotide-binding protein-like 3

Also known as: C77032, E2IG3, GNL3_HUMAN, MGC800, NS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVP2
Gene
GNL3
Ensembl
ENSG00000163938
Chromosome
3
Canonical length
549 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli rim,Nuclear bodies,Mitotic chromosome

OverviewNCBI Gene

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q9BVP2|GNL3
     1  MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV PNSAPFKEAL
    61  LREAELRKQR LEELKQQQKL DRQKELEKKR KLETNPDIKP SNVEPMEKEF GLCKTENKAK
   121  SGKQNSKKLY CQELKKVIEA SDVVLEVLDA RDPLGCRCPQ VEEAIVQSGQ KKLVLILNKS
   181  DLVPKENLES WLNYLKKELP TVVFRASTKP KDKGKITKRV KAKKNAAPFR SEVCFGKEGL
   241  WKLLGGFQET CSKAIRVGVI GFPNVGKSSI INSLKQEQMC NVGVSMGLTR SMQVVPLDKQ
   301  ITIIDSPSFI VSPLNSSSAL ALRSPASIEV VKPMEAASAI LSQADARQVV LKYTVPGYRN
   361  SLEFFTVLAQ RRGMHQKGGI PNVEGAAKLL WSEWTGASLA YYCHPPTSWT PPPYFNESIV
   421  VDMKSGFNLE ELEKNNAQSI RAIKGPHLAN SILFQSSGLT NGIIEEKDIH EELPKRKERK
   481  QEEREDDKDS DQETVDEEVD ENSSGMFAAE ETGEALSEET TAGEQSTRSF ILDKIIEEDD
   541  AYDFSTDYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 86 nTPM
  • skeletal muscle: 79 nTPM
  • esophagus: 68 nTPM
  • pancreas: 66 nTPM
  • breast: 64 nTPM
  • tonsil: 61 nTPM

Single-cell type

  • esophageal apical cells: 383 nCPM
  • urothelial cells: 282 nCPM
  • prostatic club cells: 249 nCPM
  • oocytes: 226 nCPM
  • plasma cells: 173 nCPM
  • pdcs: 168 nCPM

Immune cell

  • plasmacytoid DC: 41 nTPM
  • MAIT T-cell: 34 nTPM
  • naive CD4 T-cell: 31 nTPM
  • naive CD8 T-cell: 30 nTPM
  • memory B-cell: 29 nTPM
  • memory CD4 T-cell: 27 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • hypothalamus: 25 nTPM
  • white matter: 24 nTPM
  • choroid plexus: 24 nTPM
  • cerebellum: 23 nTPM
  • medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNL3 as an antibody target. Whether an autoantibody or antibody against GNL3 could matter depends on whether native GNL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GNL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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