Seroatlas · Human Serome Atlas

RHOBTB3

Rho-related BTB domain-containing protein 3

Also known as: KIAA0878, RHBT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94955
Gene: RHOBTB3
Ensembl: ENSG00000164292
Chromosome: 5
Canonical length: 611 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables ATP binding activity; ATP hydrolysis activity; and small GTPase binding activity. Involved in retrograde transport, endosome to Golgi. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>O94955|RHOBTB3
     1  MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA
    61  SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK
   121  RALNSVPVII AAVGTRQNEE LPCTCPLCTS DRGSCVSTTE GIQLAKELGA TYLELHSLDD
   181  FYIGKYFGGV LEYFMIQALN QKTSEKMKKR KMSNSFHGIR PPQLEQPEKM PVLKAEASHY
   241  NSDLNNLLFC CQCVDVVFYN PNLKKVVEAH KIVLCAVSHV FMLLFNVKSP TDIQDSSIIR
   301  TTQDLFAINR DTAFPGASHE SSGNPPLRVI VKDALFCSCL SDILRFIYSG AFQWEELEED
   361  IRKKLKDSGD VSNVIEKVKC ILKTPGKINC LRNCKTYQAR KPLWFYNTSL KFFLNKPMLA
   421  DVVFEIQGTT VPAHRAILVA RCEVMAAMFN GNYMEAKSVL IPVYGVSKET FLSFLEYLYT
   481  DSCCPAGIFQ AMCLLICAEM YQVSRLQHIC ELFIITQLQS MPSRELASMN LDIVDLLKKA
   541  KFHHSDCLST WLLHFIATNY LIFSQKPEFQ DLSVEERSFV EKHRWPSNMY LKQLAEYRKY
   601  IHSRKCRCLV M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOBTB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

pancreas: 105 nTPM
adipose tissue: 75 nTPM
ovary: 62 nTPM
parathyroid gland: 52 nTPM
placenta: 51 nTPM
amygdala: 48 nTPM

Single-cell type

retinal pigment epithelial cells: 865 nCPM
adipocytes: 802 nCPM
leydig cells: 791 nCPM
adrenal cortex cells: 524 nCPM
peritubular myoid cells: 519 nCPM
sertoli cells: 502 nCPM

Immune cell

eosinophil: 7.4 nTPM
gdT-cell: 1.9 nTPM
naive CD4 T-cell: 1.8 nTPM
memory CD8 T-cell: 1.6 nTPM
memory CD4 T-cell: 1.4 nTPM
non-classical monocyte: 1 nTPM

Brain region

medulla oblongata: 167 nTPM
basal ganglia: 162 nTPM
white matter: 130 nTPM
thalamus: 127 nTPM
cerebellum: 117 nTPM
amygdala: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.7
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOBTB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOBTB3 as an antibody target. Whether an autoantibody or antibody against RHOBTB3 could matter depends on whether native RHOBTB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOBTB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHOBTB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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