Seroatlas · Human Serome Atlas

GNL2

Nucleolar GTP-binding protein 2

Also known as: HUMAUANTIG, Ngp-1, Nog2, NOG2_HUMAN, Nug2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13823
Gene: GNL2
Ensembl: ENSG00000134697
Chromosome: 1
Canonical length: 731 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q13823|GNL2
     1  MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR NSRGKIIKPL
    61  QYQSTVASGT VARVEPNIKW FGNTRVIKQS SLQKFQEEMD TVMKDPYKVV MKQSKLPMSL
   121  LHDRIRPHNL KVHILDTESF ETTFGPKSQR KRPNLFASDM QSLIENAEMS TESYDQGKDR
   181  DLVTEDTGVR NEAQEEIYKK GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIETY
   241  LKKEKPWKHL IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ
   301  FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY ITLMRRIFLI
   361  DCPGVVYPSE DSETDIVLKG VVQVEKIKSP EDHIGAVLER AKPEYISKTY KIDSWENAED
   421  FLEKLAFRTG KLLKGGEPDL QTVGKMVLND WQRGRIPFFV KPPNAEPLVA PQLLPSSSLE
   481  VVPEAAQNNP GEEVTETAGE GSESIIKEET EENSHCDANT EMQQILTRVR QNFGKINVVP
   541  QFSGDDLVPV EVSDLEEELE SFSDEEEEEQ EQQRDDAEES SSEPEEENVG NDTKAVIKAL
   601  DEKIAKYQKF LDKAKAKKFS AVRISKGLSE KIFAKPEEQR KTLEEDVDDR APSKKGKKRK
   661  AQREEEQEHS NKAPRALTSK ERRRAVRQQR PKKVGVRYYE THNVKNRNRN KKKTNDSEGQ
   721  KHKRKKFRQK Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 48 nTPM
bone marrow: 47 nTPM
urinary bladder: 33 nTPM
tonsil: 31 nTPM
liver: 30 nTPM
breast: 29 nTPM

Single-cell type

oocytes: 152 nCPM
basal keratinocytes: 81 nCPM
esophageal basal cells: 81 nCPM
extravillous trophoblasts: 76 nCPM
suprabasal keratinocytes: 75 nCPM
differentiating spermatogonia: 72 nCPM

Immune cell

myeloid DC: 40 nTPM
intermediate monocyte: 36 nTPM
non-classical monocyte: 36 nTPM
NK-cell: 34 nTPM
plasmacytoid DC: 29 nTPM
T-reg: 28 nTPM

Brain region

thalamus: 18 nTPM
white matter: 17 nTPM
choroid plexus: 16 nTPM
medulla oblongata: 16 nTPM
cerebellum: 15 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -1.32
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosome biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

GTP binding domain
GTP-binding protein, orthogonal bundle domain superfamily
P-loop containing nucleoside triphosphate hydrolase
Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
TRAFAC YlqF/YawG GTPases, Ribosome Maturation
50S ribosome-binding GTPase
Nucleolar GTP-binding protein 2, N-terminal domain
Nucleolar GTP-binding protein 2, circularly permuted GTPase motif
NGP1NT (NUC091) domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNL2 as an antibody target. Whether an autoantibody or antibody against GNL2 could matter depends on whether native GNL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GNL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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