Seroatlas · Human Serome Atlas

RAB4A

Ras-related protein Rab-4A

Also known as: HRES-1/RAB4, RAB4, RAB4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20338
Gene: RAB4A
Ensembl: ENSG00000168118
Chromosome: 1
Canonical length: 218 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>P20338|RAB4A
     1  MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK
    61  YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV
   121  IILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFVQC ARKILNKIES
   181  GELDPERMGS GIQYGDAALR QLRSPRRAQA PNAQECGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 37 nTPM
heart muscle: 36 nTPM
tongue: 33 nTPM
prostate: 32 nTPM
skeletal muscle: 32 nTPM
midbrain: 29 nTPM

Single-cell type

parietal cells: 592 nCPM
gastric chief cells: 343 nCPM
platelets: 321 nCPM
lacrimal acinar cells: 304 nCPM
late spermatids: 287 nCPM
esophageal apical cells: 271 nCPM

Immune cell

eosinophil: 33 nTPM
basophil: 21 nTPM
myeloid DC: 6.8 nTPM
intermediate monocyte: 6.5 nTPM
classical monocyte: 5.5 nTPM
non-classical monocyte: 4.2 nTPM

Brain region

thalamus: 42 nTPM
midbrain: 37 nTPM
amygdala: 33 nTPM
cerebellum: 29 nTPM
white matter: 28 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.2
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB4A as an antibody target. Whether an autoantibody or antibody against RAB4A could matter depends on whether native RAB4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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