Seroatlas · Human Serome Atlas

RHOD

Rho-related GTP-binding protein RhoD

Also known as: ARHD, Rho, RHOD_HUMAN, RhoHP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00212
Gene: RHOD
Ensembl: ENSG00000173156
Chromosome: 11
Canonical length: 210 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>O00212|RHOD
     1  MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV
    61  KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK
   121  KVPIIVVGCK TDLRKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH
   181  AVFQEAAEVA LSSRGRNFWR RITQGFCVVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 186 nTPM

Expression across tissuesHPA

Tissue

esophagus: 186 nTPM
liver: 125 nTPM
vagina: 59 nTPM
skin: 58 nTPM
heart muscle: 51 nTPM
cervix: 46 nTPM

Single-cell type

esophageal apical cells: 2,153 nCPM
esophageal suprabasal cells: 439 nCPM
suprabasal keratinocytes: 187 nCPM
esophageal basal cells: 148 nCPM
ocular epithelial cells: 123 nCPM
enterocytes: 117 nCPM

Immune cell

naive CD4 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive B-cell: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 34 nTPM
cerebellum: 4.5 nTPM
medulla oblongata: 3.9 nTPM
hippocampal formation: 3.7 nTPM
amygdala: 3.1 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.02
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOD as an antibody target. Whether an autoantibody or antibody against RHOD could matter depends on whether native RHOD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOD is annotated at the cell surface, where native RHOD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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