Seroatlas · Human Serome Atlas

TOR3A

Torsin-3A

Also known as: ADIR, ADIR2, FLJ22345, TOR3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H497
Gene: TOR3A
Ensembl: ENSG00000186283
Chromosome: 1
Canonical length: 397 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homohexamer

OverviewNCBI Gene

Enables ATP hydrolysis activity. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>Q9H497|TOR3A
     1  MLRGPWRQLW LFFLLLLPGA PEPRGASRPW EGTDEPGSAW AWPGFQRLQE QLRAAGALSK
    61  RYWTLFSCQV WPDDCDEDEE AATGPLGWRL PLLGQRYLDL LTTWYCSFKD CCPRGDCRIS
   121  NNFTGLEWDL NVRLHGQHLV QQLVLRTVRG YLETPQPEKA LALSFHGWSG TGKNFVARML
   181  VENLYRDGLM SDCVRMFIAT FHFPHPKYVD LYKEQLMSQI RETQQLCHQT LFIFDEAEKL
   241  HPGLLEVLGP HLERRAPEGH RAESPWTIFL FLSNLRGDII NEVVLKLLKA GWSREEITME
   301  HLEPHLQAEI VETIDNGFGH SRLVKENLID YFIPFLPLEY RHVRLCARDA FLSQELLYKE
   361  ETLDEIAQMM VYVPKEEQLF SSQGCKSISQ RINYFLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOR3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

spleen: 48 nTPM
lymph node: 43 nTPM
tonsil: 42 nTPM
bone marrow: 38 nTPM
skeletal muscle: 31 nTPM
liver: 31 nTPM

Single-cell type

plasma cells: 169 nCPM
oocytes: 161 nCPM
cdc: 84 nCPM
extravillous trophoblasts: 72 nCPM
hofbauer cells: 66 nCPM
pdcs: 64 nCPM

Immune cell

memory B-cell: 98 nTPM
plasmacytoid DC: 93 nTPM
myeloid DC: 86 nTPM
naive B-cell: 74 nTPM
classical monocyte: 71 nTPM
non-classical monocyte: 60 nTPM

Brain region

hypothalamus: 25 nTPM
white matter: 24 nTPM
choroid plexus: 24 nTPM
medulla oblongata: 22 nTPM
spinal cord: 20 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOR3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TOR1AIP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOR3A as an antibody target. Whether an autoantibody or antibody against TOR3A could matter depends on whether native TOR3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOR3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOR3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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