ARL5B
ADP-ribosylation factor-like protein 5B
Also known as: ARL5B_HUMAN, ARL8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96KC2
- Gene
- ARL5B
- Ensembl
- ENSG00000165997
- Chromosome
- 10
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>Q96KC2|ARL5B
1 MGLIFAKLWS LFCNQEHKVI IVGLDNAGKT TILYQFLMNE VVHTSPTIGS NVEEIVVKNT
61 HFLMWDIGGQ ESLRSSWNTY YSNTEFIILV VDSIDRERLA ITKEELYRML AHEDLRKAAV
121 LIFANKQDMK GCMTAAEISK YLTLSSIKDH PWHIQSCCAL TGEGLCQGLE WMTSRIGVRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- liver: 28 nTPM
- adrenal gland: 20 nTPM
- bone marrow: 19 nTPM
- gallbladder: 13 nTPM
- thymus: 13 nTPM
- placenta: 12 nTPM
Single-cell type
- endometrial glandular cells: 441 nCPM
- neutrophils: 390 nCPM
- ocular epithelial cells: 375 nCPM
- urothelial cells: 358 nCPM
- epididymal basal cells: 305 nCPM
- endometrial luminal cells: 268 nCPM
Immune cell
- basophil: 1.2 nTPM
- NK-cell: 1 nTPM
- myeloid DC: 0.9 nTPM
- naive CD4 T-cell: 0.9 nTPM
- neutrophil: 0.9 nTPM
- intermediate monocyte: 0.8 nTPM
Brain region
- cerebellum: 14 nTPM
- cerebral cortex: 14 nTPM
- choroid plexus: 12 nTPM
- white matter: 11 nTPM
- hypothalamus: 11 nTPM
- spinal cord: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.05
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.46
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL5B as an antibody target. Whether an autoantibody or antibody against ARL5B could matter depends on whether native ARL5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARL5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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