Seroatlas · Human Serome Atlas

KIF12

Kinesin-like protein KIF12

Also known as: KIF12_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FN5
Gene: KIF12
Canonical length: 646 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KIF12 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>Q96FN5|KIF12
     1  MEERGSPDGD LARSLEQGPE GPETPIQVVL RVRPMSAAEL RRGQQSVLHC SGTRTLQGGP
    61  EVAFRFGAVL DAARTQEDVF RACGVRRLGE LALRGFSCTV FTFGQTGSGK TYTLTGPPPQ
   121  GEGVPVPPSL AGIMQRTFAW LLDRVQHLGA PVTLRASYLE IYNEQVRDLL SLGSPRPLPV
   181  RWNKTRGFYV EQLRVVEFGS LEALMELLQT GLSRRRNSAH TLNQASSRSH ALLTLYISRQ
   241  TAQQMPSVDP GEPPVGGKLC FVDLAGSEKV AATGSRGELM LEANSINRSL LALGHCISLL
   301  LDPQRKQSHI PFRDSKLTKL LADSLGGRGV TLMVACVSPS AQCLPETLST LRYASRAQRV
   361  TTRPQAPKSP VAKQPQRLET EMLQLQEENR RLQFQLDQMD CKASGLSGAR VAWAQRNLYG
   421  MLQEFMLENE RLRKEKSQLQ NSRDLAQNEQ RILAQQVHAL ERRLLSACYH HQQGPGLTPP
   481  CPCLMAPAPP CHALPPLYSC PCCHICPLCR VPLAHWACLP GEHHLPQVLD PEASGGRPPS
   541  ARPPPWAPPC SPGSAKCPRE RSHSDWTQTR VLAEMLTEEE VVPSAPPLPV RPPKTSPGLR
   601  GGAGVPNLAQ RLEALRDQIG SSLRRGRSQP PCSEGARSPG QVLPPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 214 nTPM

Expression across tissuesHPA

Tissue

kidney: 214 nTPM
pancreas: 92 nTPM
liver: 37 nTPM
thyroid gland: 33 nTPM
breast: 23 nTPM
duodenum: 13 nTPM

Single-cell type

proximal tubule cells: 215 nCPM
cholangiocytes: 115 nCPM
renal connecting tubule cells: 98 nCPM
distal convoluted tubule cells: 95 nCPM
loop of henle epithelial cells: 94 nCPM
neuroendocrine cells: 87 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 5.2 nTPM
amygdala: 4 nTPM
cerebral cortex: 3.8 nTPM
basal ganglia: 3.7 nTPM
hypothalamus: 2.4 nTPM
hippocampal formation: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF12.

Disease | AllUniProt

Conditions KIF12 is implicated in, by any mechanism.

Cholestasis, progressive familial intrahepatic, 8 (PFIC8) MIM:619662

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 181 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cholestasis, progressive familial intrahepatic, 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF12 as an antibody target. Whether an autoantibody or antibody against KIF12 could matter depends on whether native KIF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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