MYO16

Protein identityUniProt · HPA

UniProt accession

Q9Y6X6

Gene

MYO16

Ensembl

ENSG00000041515

Chromosome

13

Canonical length

1858 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

1858 residues, UniProt reviewed canonical sequence.

>Q9Y6X6|MYO16
     1  MEIDQCLLES LPLGQRQRLV KRMRCEQIKA YYEREKAFQK QEGFLKRLKH AKNPKVHFNL
    61  TDMLQDAIIH HNDKEVLRLL KEGADPHTLV SSGGSLLHLC ARYDNAFIAE ILIDRGVNVN
   121  HQDEDFWTPM HIACACDNPD IVLLLVLAGA NVLLQDVNGN IPLDYAVEGT ESSSILLTYL
   181  DENGVDLTSL RQMKLQRPMS MLTDVKHFLS SGGNVNEKND EGVTLLHMAC ASGYKEVVSL
   241  ILEHGGDLNI VDDQYWTPLH LAAKYGQTNL VKLLLMHQAN PHLVNCNEEK ASDIAASEFI
   301  EEMLLKAEIA WEEKMKEPLS ASTLAQEEPY EEIIHDLPVL SSKLSPLVLP IAKQDSLLEK
   361  DIMFKDATKG LCKQQSQDSI PENPMMSGST KPEQVKLMPP APNDDLATLS ELNDGSLLYE
   421  IQKRFGNNQI YTFIGDILLL VNPYKELPIY SSMVSQLYFS SSGKLCSSLP PHLFSCVERA
   481  FHQLFREQRP QCFILSGERG SGKSEASKQI IRHLTCRAGA SRATLDSRFK HVVCILEAFG
   541  HAKTTLNDLS SCFIKYFELQ FCERKQQLTG ARIYTYLLEK SRLVSQPLGQ SNFLIFYLLM
   601  DGLSAEEKYG LHLNNLCAHR YLNQTIQDDA STGERSLNRE KLAVLKRALN VVGFSSLEVE
   661  NLFVILAAIL HLGDIRFTAL NEGNSAFVSD LQLLEQVAGM LQVSTDELAS ALTTDIQYFK
   721  GDMIIRRHTI QIAEFFRDLL AKSLYSRLFS FLVNTMNSCL HSQDEQKSMQ TLDIGILDIF
   781  GFEEFQKNEF EQLCVNMTNE KMHHYINEVL FLHEQVECVQ EGVTMETAYS PGNQNGVLDF
   841  FFQKPSGFLT LLDEESQMIW SVESNFPKKL QSLLESSNTN AVYSPMKDGN GNVALKDHGT
   901  AFTIMHYAGR VMYDVVGAIE KNKDSLSQNL LFVMKTSENV VINHLFQSKL SQTGSLVSAY
   961  PSFKFRGHKS ALLSKKMTAS SIIGENKNYL ELSKLLKKKG TSTFLQRLER GDPVTIASQL
  1021  RKSLMDIIGK LQKCTPHFIH CIRPNNSKLP DTFDNFYVSA QLQYIGVLEM VKIFRYGYPV
  1081  RLSFSDFLSR YKPLADTFLR EKKEQSAAER CRLVLQQCKL QGWQMGVRKV FLKYWHADQL
  1141  NDLCLQLQRK IITCQKVIRG FLARQHLLQR ISIRQQEVTS INSFLQNTED MGLKTYDALV
  1201  IQNASDIARE NDRLRSEMNA PYHKEKLEVR NMQEEGSKRT DDKSGPRHFH PSSMSVCAAV
  1261  DGLGQCLVGP SIWSPSLHSV FSMDDSSSLP SPRKQPPPKP KRDPNTRLSA SYEAVSACLS
  1321  AAREAANEAL ARPRPHSDDY STMKKIPPRK PKRSPNTKLS GSYEEISGSR PGDARPAGAP
  1381  GAAARVLTPG TPQCALPPAA PPGDEDDSEP VYIEMLGHAA RPDSPDPGES VYEEMKCCLP
  1441  DDGGPGAGSF LLHGASPPLL HRAPEDEAAG PPGDACDIPP PFPNLLPHRP PLLVFPPTPV
  1501  TCSPASDESP LTPLEVKKLP VLETNLKYPV QPEGSSPLSP QYSKSQKGDG DRPASPGLAL
  1561  FNGSGRASPP STPPPPPPPP GPPPAPYRPC AHLAFPPEPA PVNAGKAGPS AEAPKVHPKP
  1621  NSAPVAGPCS SFPKIPYSPV KATRADARKA GSSASPPAPY SPPSSRPLSS PLDELASLFN
  1681  SGRSVLRKSA AGRKIREAEG FETNMNISSR DDPSTSEITS ETQDRNANNH GIQLSNSLSS
  1741  AITAENGNSI SNGLPEEDGY SRLSISGTGT STFQRHRDSH TTQVIHQLRL SENESVALQE
  1801  LLDWRRKLCE EGQDWQQILH HAEPRVPPPP PCKKPSLLKK PEGASCNRLP SELWDTTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

2.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYO16.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 407 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• MYO16-associated developmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

1.03

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cerebellum development
• negative regulation of cell population proliferation
• negative regulation of G1/S transition of mitotic cell cycle
• neuron projection morphogenesis
• phosphatidylinositol 3-kinase/protein kinase B signal transduction

Molecular functions

• actin filament binding
• ATP binding
• cytoskeletal motor activity
• protein phosphatase binding

Cellular components

• cytoplasm
• myosin complex
• nucleoplasm
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Myosin head, motor domain-like
• Ankyrin repeat
• P-loop containing nucleoside triphosphate hydrolase
• Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain
• Ankyrin repeat-containing domain superfamily
• Kinesin motor domain superfamily
• Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, N-terminal
• Myosin head (motor domain)
• Ankyrin repeats (3 copies)
• Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
• Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
• Class XVI myosin, motor domain
• Unconventional myosin-XVI

KeywordsUniProt

• Actin-binding
• ANK repeat
• ATP-binding
• Cytoplasm
• Motor protein
• Myosin
• Nucleotide-binding
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of MYO16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACOT9
• ARHGAP26
• CYFIP1
• KIRREL3
• NCKAP1
• PIK3R2