Seroatlas · Human Serome Atlas

AK9

Adenylate kinase 9

Also known as: AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1, FLJ25791, FLJ42177, KAD9_HUMAN, MGC26954

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TCS8
Gene
AK9
Ensembl
ENSG00000155085
Chromosome
6
Canonical length
1911 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol,Calyx

OverviewNCBI Gene

The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

1911 residues, UniProt reviewed canonical sequence.

>Q5TCS8|AK9
     1  MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE
    61  ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL
   121  SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV
   181  IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI
   241  VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG
   301  AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL
   361  GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV
   421  DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK
   481  MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE
   541  TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP
   601  YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL
   661  SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEEARKATEE ELRLEEENRR
   721  LLELMKVKAK EAEETDNEDE EEIEGDELEV HEEPEASHDT RGSWLPEEFE ASEVPETEPE
   781  AVSEPIEETT VETEIPKGSK EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII
   841  LWKQLEATIS EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY
   901  QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN TEEAAKYREK
   961  IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ GSGKTMCGRQ LAEKLNIFHI
  1021  QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ AAKQELEELA IQANVKVEEE NTKKQLPEVQ
  1081  LTEEEEVIKS SLMENEPLPP EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG
  1141  FFPDAAVFIQ VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE
  1201  LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE EDEEQETDAI
  1261  ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR NHIVQYTLNM KLKPLVENRA
  1321  SIFEKCHPIP APLAQKMLTF TYKYISSFGY WDPVKLSEGE TIKPVENAEN PIYPVIHRQY
  1381  IYFLSSKETK EKFMKNPIKY IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL
  1441  SIGGALRYVL NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY
  1501  PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN SAQIVAVNNV
  1561  KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV QMVNKYMQTY LERIKAGKAA
  1621  CIDKLCITPQ ELLSRLGEFE QFCPVSLAES QELFDCSATD SLEFAAEFRG HYYKMSSQEK
  1681  LNKFLENPEL YVPPLAPHPL PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY
  1741  EALVPGSINY ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL
  1801  PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG SEYTRKKYKK
  1861  KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF LSLRNIDPIN G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AK9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • choroid plexus: 15 nTPM
  • retina: 13 nTPM
  • parathyroid gland: 8.6 nTPM
  • fallopian tube: 7.4 nTPM
  • pituitary gland: 7.2 nTPM

Single-cell type

  • respiratory ciliated cells: 520 nCPM
  • ependymal cells: 354 nCPM
  • early primary spermatocytes: 253 nCPM
  • choroid plexus epithelial cells: 212 nCPM
  • fallopian tube ciliated cells: 210 nCPM
  • endometrial ciliated cells: 208 nCPM

Immune cell

  • basophil: 17 nTPM
  • memory B-cell: 13 nTPM
  • naive B-cell: 11 nTPM
  • eosinophil: 7.1 nTPM
  • naive CD4 T-cell: 6.3 nTPM
  • memory CD8 T-cell: 6.1 nTPM

Brain region

  • cerebellum: 40 nTPM
  • white matter: 38 nTPM
  • spinal cord: 34 nTPM
  • choroid plexus: 34 nTPM
  • hypothalamus: 34 nTPM
  • midbrain: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AK9.

Disease | AllUniProt

Conditions AK9 is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 250 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 89

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
2.19
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AK9 as an antibody target. Whether an autoantibody or antibody against AK9 could matter depends on whether native AK9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AK9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AK9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AK9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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