Seroatlas · Human Serome Atlas

GIMAP2

GTPase IMAP family member 2

Also known as: DKFZp586D0824, GIMA2_HUMAN, HIMAP2, IAN12, IMAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UG22
Gene: GIMAP2
Ensembl: ENSG00000106560
Chromosome: 7
Canonical length: 337 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Lipid droplets
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9UG22|GIMAP2
     1  MDQNEHSHWG PHAKGQCASR SELRIILVGK TGTGKSAAGN SILRKQAFES KLGSQTLTKT
    61  CSKSQGSWGN REIVIIDTPD MFSWKDHCEA LYKEVQRCYL LSAPGPHVLL LVTQLGRYTS
   121  QDQQAAQRVK EIFGEDAMGH TIVLFTHKED LNGGSLMDYM HDSDNKALSK LVAACGGRIC
   181  AFNNRAEGSN QDDQVKELMD CIEDLLMEKN GDHYTNGLYS LIQRSKCGPV GSDERVKEFK
   241  QSLIKYMETQ RSYTALAEAN CLKGALIKTQ LCVLFCIQLF LRLIILWLCI LHSMCNLFCC
   301  LLFSMCNLFC SLLFIIPKKL MIFLRTVIRL ERKTPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

lymph node: 73 nTPM
spleen: 59 nTPM
tonsil: 54 nTPM
thymus: 47 nTPM
appendix: 38 nTPM
lung: 21 nTPM

Single-cell type

kupffer cells: 203 nCPM
monocytes: 59 nCPM
hematopoietic stem cells: 56 nCPM
t-cells: 49 nCPM
thymocytes: 48 nCPM
hofbauer cells: 47 nCPM

Immune cell

naive CD4 T-cell: 167 nTPM
NK-cell: 137 nTPM
total PBMC: 130 nTPM
naive CD8 T-cell: 125 nTPM
memory CD4 T-cell: 122 nTPM
non-classical monocyte: 122 nTPM

Brain region

medulla oblongata: 11 nTPM
white matter: 9.5 nTPM
pons: 9 nTPM
spinal cord: 9 nTPM
midbrain: 7.1 nTPM
thalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.41
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP2 as an antibody target. Whether an autoantibody or antibody against GIMAP2 could matter depends on whether native GIMAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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