Seroatlas · Human Serome Atlas

ZFYVE1

Zinc finger FYVE domain-containing protein 1

Also known as: DFCP1, KIAA1589, PPP1R172, TAFF1, ZFYV1_HUMAN, ZNFN2A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBF4
Gene
ZFYVE1
Ensembl
ENSG00000165861
Chromosome
14
Canonical length
777 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q9HBF4|ZFYVE1
     1  MSAQTSPAEK GLNPGLMCQE SYACSGTDEA IFECDECCSL QCLRCEEELH RQERLRNHER
    61  IRLKPGHVPY CDLCKGLSGH LPGVRQRAIV RCQTCKINLC LECQKRTHSG GNKRRHPVTV
   121  YNVSNLQESL EAEEMDEETK RKKMTEKVVS FLLVDENEEI QVTNEEDFIR KLDCKPDQHL
   181  KVVSIFGNTG DGKSHTLNHT FFYGREVFKT SPTQESCTVG VWAAYDPVHK VAVIDTEGLL
   241  GATVNLSQRT RLLLKVLAIS DLVIYRTHAD RLHNDLFKFL GDASEAYLKH FTKELKATTA
   301  RCGLDVPLST LGPAVIIFHE TVHTQLLGSD HPSEVPEKLI QDRFRKLGRF PEAFSSIHYK
   361  GTRTYNPPTD FSGLRRALEQ LLENNTTRSP RHPGVIFKAL KALSDRFSGE IPDDQMAHSS
   421  FFPDEYFTCS SLCLSCGVGC KKSMNHGKEG VPHEAKSRCR YSHQYDNRVY TCKACYERGE
   481  EVSVVPKTSA STDSPWMGLA KYAWSGYVIE CPNCGVVYRS RQYWFGNQDP VDTVVRTEIV
   541  HVWPGTDGFL KDNNNAAQRL LDGMNFMAQS VSELSLGPTK AVTSWLTDQI APAYWRPNSQ
   601  ILSCNKCATS FKDNDTKHHC RACGEGFCDS CSSKTRPVPE RGWGPAPVRV CDNCYEARNV
   661  QLAVTEAQVD DEGGTLIARK VGEAVQNTLG AVVTAIDIPL GLVKDAARPA YWVPDHEILH
   721  CHNCRKEFSI KLSKHHCRAC GQGFCDECSH DRRAVPSRGW DHPVRVCFNC NKKPGDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFYVE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • testis: 16 nTPM
  • skeletal muscle: 16 nTPM
  • adrenal gland: 13 nTPM
  • skin: 13 nTPM
  • tongue: 13 nTPM
  • blood vessel: 12 nTPM

Single-cell type

  • late spermatids: 181 nCPM
  • esophageal apical cells: 83 nCPM
  • proximal tubule cells: 70 nCPM
  • early spermatids: 56 nCPM
  • renal collecting duct intercalated cells: 53 nCPM
  • adrenal cortex cells: 50 nCPM

Immune cell

  • neutrophil: 11 nTPM
  • eosinophil: 9.6 nTPM
  • classical monocyte: 7 nTPM
  • gdT-cell: 6.7 nTPM
  • intermediate monocyte: 6.3 nTPM
  • myeloid DC: 6.1 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • thalamus: 22 nTPM
  • midbrain: 22 nTPM
  • basal ganglia: 22 nTPM
  • hypothalamus: 22 nTPM
  • pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.2
gnomAD missense Z
2.82
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFYVE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFYVE1 as an antibody target. Whether an autoantibody or antibody against ZFYVE1 could matter depends on whether native ZFYVE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFYVE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFYVE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZFYVE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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