Seroatlas · Human Serome Atlas

DIRAS3

GTP-binding protein Di-Ras3

Also known as: ARHI, DIRA3_HUMAN, NOEY2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95661
Gene: DIRAS3
Ensembl: ENSG00000162595
Chromosome: 1
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>O95661|DIRAS3
     1  MGNASFGSKE QKLLKRLRLL PALLILRAFK PHRKIRDYRV VVVGTAGVGK STLLHKWASG
    61  NFRHEYLPTI ENTYCQLLGC SHGVLSLHIT DSKSGDGNRA LQRHVIARGH AFVLVYSVTK
   121  KETLEELKAF YELICKIKGN NLHKFPIVLV GNKSDDTHRE VALNDGATCA MEWNCAFMEI
   181  SAKTDVNVQE LFHMLLNYKK KPTTGLQEPE KKSQMPNTTE KLLDKCIIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIRAS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 184 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 184 nTPM
basal ganglia: 79 nTPM
pituitary gland: 66 nTPM
ovary: 50 nTPM
pancreas: 21 nTPM
adrenal gland: 19 nTPM

Single-cell type

other brain neurons: 118 nCPM
ovarian stromal cells: 84 nCPM
gonadotrophs: 64 nCPM
epididymal basal cells: 48 nCPM
neuroendocrine cells: 39 nCPM
pancreatic acinar cells: 37 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
T-reg: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 303 nTPM
midbrain: 100 nTPM
medulla oblongata: 81 nTPM
thalamus: 60 nTPM
basal ganglia: 48 nTPM
pons: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIRAS3 as an antibody target. Whether an autoantibody or antibody against DIRAS3 could matter depends on whether native DIRAS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIRAS3 is annotated at the cell surface, where native DIRAS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DIRAS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...