DDX11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8
Also known as: D11L8_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DDX11L8 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
907 residues, UniProt reviewed canonical sequence.
>A8MPP1|DDX11L8
1 MANETQKVGA IHFPFPFTPY SIQEDFMAEL YRVLEAGKIG IFESPTGTGK SLSLICGALS
61 WLRDFEQKKR EEEARLLETG TGPLHDEKDE SLCLSSSCEG AAGTPRPAGE PAWVTQFVQK
121 KEERDLVDRL KVEQARRKQR EERLQQLQHR VQLKYAAKRL RQEEEETENL LRLSREMLET
181 GPEAERLEQL ESGEEELVLA EYESDEEKKV ASGHRVDEDE DDLEEEHITK IYHCSRTHSQ
241 LAQFVHEVKK SPFGKDVRLV SLGSRQNLCV NEDVRSLGSV QLINDRCVDM QRSRHEKKKG
301 AEEEKPKRRR QEKQAACPFY NHEQMGLLRD EALAEVKDME QLLALGKEAR ACPYYRSRLA
361 IPAAKLVVLP YQMLLHAATR QAAGIRLQDQ VVIIDEAHNL IDTITGMHSV EVSGSQLCQA
421 HSQLLQYMER YGKRLKAKNL MYLKQILYLL EKFVAVLGGN IKQNPNTQSL SQTGTELKTI
481 NDFLFQSQID NINLFKVQRY CEKSMISRKL FGFTERYGAV FSSREQPKLA GFQQFLQSLQ
541 PRTTEALAAP ADESQASVPQ PASPLMHIEG FLAALTTANQ DGRVILSRQG SLSESTLKFL
601 LLNPAVHFAQ VVKECRAVVI AGGTMQPVSD FRQQLLACAG VEAERVVEFS CGHVIPPDNI
661 PLVICSGISN QPLEFTFQKR DLPQMMDEVG RILCNLCGVV SGGVVCFFSS YEYLRQVHAH
721 WEKGGLLGRL AARKKIFQEP KSAHQVEQVL LAYSRCIQAC GQERGQVTEA LLLSVVGGKM
781 SEGINFSDNL GRCVVMVGMP FPNIRSAELQ EKMAYLDQTL PRAPGQAPPG KALVENLCMK
841 AVNQSIGRAI RHQKDFASIV LLDQRYARPP VLAKLPAWIR ASVEVKATFG PAIAAVQKFH
901 REKSASSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DDX11L8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
OntologyGO
Biological processes
Molecular functions
- ATP binding
- DNA binding
- DNA helicase activity
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- iron-sulfur cluster binding
- metal ion binding
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Helicase-like, DEXD box c2 type
- ATP-dependent helicase, C-terminal
- RAD3-like helicase, DEAD
- ATP-dependent helicase Rad3/Chl1-like
- Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
- P-loop containing nucleoside triphosphate hydrolase
- Helicase superfamily 1/2, DinG/Rad3-like
- DEAD_2
- Helicase C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DDX11L8 as an antibody target. Whether an autoantibody or antibody against DDX11L8 could matter depends on whether native DDX11L8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DDX11L8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DDX11L8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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