Seroatlas · Human Serome Atlas

RAB2A

Ras-related protein Rab-2A

Also known as: RAB2, RAB2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61019
Gene
RAB2A
Ensembl
ENSG00000104388
Chromosome
8
Canonical length
212 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P61019|RAB2A
     1  MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI DGKQIKLQIW
    61  DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK
   121  SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN
   181  EANGIKIGPQ HAATNATHAG NQGGQQAGGG CC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 113 nTPM
  • esophagus: 83 nTPM
  • blood vessel: 77 nTPM
  • cerebral cortex: 70 nTPM
  • adipose tissue: 67 nTPM
  • liver: 66 nTPM

Single-cell type

  • esophageal apical cells: 2,186 nCPM
  • neutrophils: 1,168 nCPM
  • syncytiotrophoblasts: 804 nCPM
  • extravillous trophoblasts: 706 nCPM
  • esophageal suprabasal cells: 644 nCPM
  • neutrophil progenitors: 623 nCPM

Immune cell

  • neutrophil: 313 nTPM
  • eosinophil: 242 nTPM
  • basophil: 231 nTPM
  • classical monocyte: 165 nTPM
  • non-classical monocyte: 153 nTPM
  • intermediate monocyte: 150 nTPM

Brain region

  • hypothalamus: 112 nTPM
  • cerebral cortex: 107 nTPM
  • hippocampal formation: 103 nTPM
  • basal ganglia: 103 nTPM
  • pons: 97 nTPM
  • spinal cord: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
2.99
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB2A as an antibody target. Whether an autoantibody or antibody against RAB2A could matter depends on whether native RAB2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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