Seroatlas · Human Serome Atlas

NKIRAS2

NF-kappa-B inhibitor-interacting Ras-like protein 2

Also known as: DKFZP434N1526, kappaB-Ras2, KBRAS2, KBRS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYR9
Gene: NKIRAS2
Ensembl: ENSG00000168256
Chromosome: 17
Canonical length: 191 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within several processes, including lung alveolus development; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q9NYR9|NKIRAS2
     1  MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD RGVREQVRFY
    61  DTRGLRDGAE LPRHCFSCTD GYVLVYSTDS RESFQRVELL KKEIDKSKDK KEVTIVVLGN
   121  KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS VADRRSLLEP FVYLASKMTQ PQSKSAFPLS
   181  RKNKGSGSLD G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NKIRAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
heart muscle: 43 nTPM
esophagus: 35 nTPM
tongue: 34 nTPM
placenta: 32 nTPM
blood vessel: 28 nTPM

Single-cell type

esophageal apical cells: 122 nCPM
megakaryocytes: 80 nCPM
syncytiotrophoblasts: 78 nCPM
cytotrophoblasts: 63 nCPM
late primary spermatocytes: 54 nCPM
migrating cytotrophoblasts: 52 nCPM

Immune cell

basophil: 54 nTPM
classical monocyte: 54 nTPM
non-classical monocyte: 50 nTPM
plasmacytoid DC: 48 nTPM
eosinophil: 46 nTPM
intermediate monocyte: 45 nTPM

Brain region

basal ganglia: 31 nTPM
thalamus: 29 nTPM
cerebral cortex: 28 nTPM
choroid plexus: 27 nTPM
medulla oblongata: 27 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.01
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NKIRAS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NKIRAS2 as an antibody target. Whether an autoantibody or antibody against NKIRAS2 could matter depends on whether native NKIRAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NKIRAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NKIRAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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