Seroatlas · Human Serome Atlas

NLRP14

NACHT, LRR and PYD domains-containing protein 14

Also known as: CLR11.2, GC-LRR, NAL14_HUMAN, Nalp-iota, NALP14, NOD5, PAN8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86W24
Gene: NLRP14
Ensembl: ENSG00000158077
Chromosome: 11
Canonical length: 1093 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1093 residues, UniProt reviewed canonical sequence.

>Q86W24|NLRP14
     1  MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV KKARREDLAN
    61  LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ TIGPDDAKAG ETQEDQEAVL
   121  GDGTEYRNRI KEKFCITWDK KSLAGKPEDF HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV
   181  LQGAAGVGKT TLVRKAMLDW AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST
   241  EGPIEEIMYQ PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE
   301  ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM KVFSSLKSNE
   361  MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF TCYISSLFTP VDGGSPSLPN
   421  QAQLRRLCQV AAKGIWTMTY VFYRENLRRL GLTQSDVSSF MDSNIIQKDA EYENCYVFTH
   481  LHVQEFFAAM FYMLKGSWEA GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR
   541  VKQLERTFNC KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR
   601  CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT NTWDGDRITH
   661  CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP NCKLQKLLLK FITFPDGCQD
   721  ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC EALKHPECKL QTLRLESCNL TVFCCLNISN
   781  ALIRSQSLIF LNLSTNNLLD DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI
   841  SNKRLTHLCL ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK
   901  SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA SVILNNPNLR
   961  SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS LCCQDLSSAL ICNKRLIKMN
  1021  LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN
  1081  YHNEEDVSWW WCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

retina: 0.9 nTPM
testis: 0.8 nTPM
liver: 0.5 nTPM
kidney: 0.3 nTPM
ovary: 0.3 nTPM
thymus: 0.3 nTPM

Single-cell type

oocytes: 9.2 nCPM
proximal tubule cells: 7 nCPM
ependymal cells: 6.8 nCPM
plasma cells: 5.8 nCPM
renal collecting duct intercalated cells: 5.8 nCPM
early primary spermatocytes: 5.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.2 nTPM
medulla oblongata: 0.9 nTPM
midbrain: 0.9 nTPM
spinal cord: 0.9 nTPM
hypothalamus: 0.7 nTPM
basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLRP14 as an antibody target. Whether an autoantibody or antibody against NLRP14 could matter depends on whether native NLRP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLRP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NLRP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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